Email this article Effect of Lithium Preparations on Cerebral Electrophysiological Activity in Rats
- Authors: Konenkov V.I.1, Rachkovskaya L.N.1, Letyagin A.Y.1, Suslov N.I.2, Shurlygina A.V.1, Robinson M.V.1, Korolev M.A.1, Kotlyarova A.A.1, Popova T.V.1, Rachkovskii E.E.1, Povet’eva T.N.2, Shilova N.V.2, Nesterova Y.V.2, Afanas’eva O.G.2, Kul’pin P.V.2
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Affiliations:
- Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
- Issue: Vol 165, No 4 (2018)
- Pages: 470-473
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240426
- DOI: https://doi.org/10.1007/s10517-018-4196-5
- ID: 240426
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Abstract
The study examined the effects of a novel neurotropic medication based on a lithium complex composed of lithium citrate, polymethylsiloxane, and aluminum oxide on electrophysiological parameters of the rat brain. In contrast to lithium carbonate (the reference drug), the novel preparation resulted in a wave-like dynamics of electrical activity in the visual cortex. Rhythmic photic stimulation of the rats treated with lithium carbonate resulted in appearance of the signs attesting to up-regulation of excitability of cerebral cortex in all examined ranges. In contrast, the complex lithium preparation diminished the delta power spectrum, which was the only affected frequency band. It is hypothesized that the complex lithium medication induces milder activation of the cerebral cortex in comparison with lithium carbonate. The novel medication composed of lithium citrate, aluminum oxide, and polymethylsiloxane, is characterized by greater efficacy and safety than the preparation based on inorganic lithium salt (lithium carbonate).
About the authors
V. I. Konenkov
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: anna_v_s@mail.ru
Russian Federation, Novosibirsk
L. N. Rachkovskaya
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: anna_v_s@mail.ru
Russian Federation, Novosibirsk
A. Yu. Letyagin
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: anna_v_s@mail.ru
Russian Federation, Novosibirsk
N. I. Suslov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: anna_v_s@mail.ru
Russian Federation, Tomsk
A. V. Shurlygina
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Author for correspondence.
Email: anna_v_s@mail.ru
Russian Federation, Novosibirsk
M. V. Robinson
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: anna_v_s@mail.ru
Russian Federation, Novosibirsk
M. A. Korolev
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: anna_v_s@mail.ru
Russian Federation, Novosibirsk
A. A. Kotlyarova
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: anna_v_s@mail.ru
Russian Federation, Novosibirsk
T. V. Popova
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: anna_v_s@mail.ru
Russian Federation, Novosibirsk
E. E. Rachkovskii
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: anna_v_s@mail.ru
Russian Federation, Novosibirsk
T. N. Povet’eva
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: anna_v_s@mail.ru
Russian Federation, Tomsk
N. V. Shilova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: anna_v_s@mail.ru
Russian Federation, Tomsk
Yu. V. Nesterova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: anna_v_s@mail.ru
Russian Federation, Tomsk
O. G. Afanas’eva
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: anna_v_s@mail.ru
Russian Federation, Tomsk
P. V. Kul’pin
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: anna_v_s@mail.ru
Russian Federation, Tomsk
