Expression of Bcl-2 Family Proteins in the Ovarian Follicular Apparatus in the Acute Period after Experimental Hyperthermia
- Авторлар: Michurina S.1, Kolesnikov S.2, Bochkareva A.1, Arkhipov S.1, Ishchenko I.1
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Мекемелер:
- Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of the Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science
- Research Center for Family Health and Human Reproduction Problems
- Шығарылым: Том 164, № 6 (2018)
- Беттер: 780-783
- Бөлім: Morphology and Pathomorphology
- URL: https://journals.rcsi.science/0007-4888/article/view/239909
- DOI: https://doi.org/10.1007/s10517-018-4079-9
- ID: 239909
Дәйексөз келтіру
Аннотация
The expression of apoptosis regulators (proapoptotic protein Bad and anti-apoptotic protein Bcl-2) was analyzed and Bcl-2/Bad ratio in the follicular apparatus of the rat ovary was determined on day 3 after hyperthermia (rectal temperature 43.5°C). Hyperthermia in the catabolic phase leads to different degrees of activation of the molecular “switches” of apoptosis in cells of ovarian follicular epithelium. This was seen from increased intensity of immunohistochemical staining for Bad protein against the background of more pronounced expression of Bcl-2 protein. On day 3 after exposure to hyperthermia, Bcl-2/Bad ratio increased, which reflects antiapoptotic protection of cells and conditions for blockade of mitochondrial pathway of apoptosis in the follicular apparatus of the ovaries during the acute period after hyperthermia.
Авторлар туралы
S. Michurina
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of the Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science
Хат алмасуға жауапты Автор.
Email: s.michurina@ngs.ru
Ресей, Novosibirsk
S. Kolesnikov
Research Center for Family Health and Human Reproduction Problems
Email: s.michurina@ngs.ru
Ресей, Irkutsk
A. Bochkareva
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of the Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science
Email: s.michurina@ngs.ru
Ресей, Novosibirsk
S. Arkhipov
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of the Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science
Email: s.michurina@ngs.ru
Ресей, Novosibirsk
I. Ishchenko
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of the Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science
Email: s.michurina@ngs.ru
Ресей, Novosibirsk
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