Expression of Bcl-2 Family Proteins in the Ovarian Follicular Apparatus in the Acute Period after Experimental Hyperthermia
- Autores: Michurina S.1, Kolesnikov S.2, Bochkareva A.1, Arkhipov S.1, Ishchenko I.1
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Afiliações:
- Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of the Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science
- Research Center for Family Health and Human Reproduction Problems
- Edição: Volume 164, Nº 6 (2018)
- Páginas: 780-783
- Seção: Morphology and Pathomorphology
- URL: https://journals.rcsi.science/0007-4888/article/view/239909
- DOI: https://doi.org/10.1007/s10517-018-4079-9
- ID: 239909
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Resumo
The expression of apoptosis regulators (proapoptotic protein Bad and anti-apoptotic protein Bcl-2) was analyzed and Bcl-2/Bad ratio in the follicular apparatus of the rat ovary was determined on day 3 after hyperthermia (rectal temperature 43.5°C). Hyperthermia in the catabolic phase leads to different degrees of activation of the molecular “switches” of apoptosis in cells of ovarian follicular epithelium. This was seen from increased intensity of immunohistochemical staining for Bad protein against the background of more pronounced expression of Bcl-2 protein. On day 3 after exposure to hyperthermia, Bcl-2/Bad ratio increased, which reflects antiapoptotic protection of cells and conditions for blockade of mitochondrial pathway of apoptosis in the follicular apparatus of the ovaries during the acute period after hyperthermia.
Sobre autores
S. Michurina
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of the Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science
Autor responsável pela correspondência
Email: s.michurina@ngs.ru
Rússia, Novosibirsk
S. Kolesnikov
Research Center for Family Health and Human Reproduction Problems
Email: s.michurina@ngs.ru
Rússia, Irkutsk
A. Bochkareva
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of the Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science
Email: s.michurina@ngs.ru
Rússia, Novosibirsk
S. Arkhipov
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of the Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science
Email: s.michurina@ngs.ru
Rússia, Novosibirsk
I. Ishchenko
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of the Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science
Email: s.michurina@ngs.ru
Rússia, Novosibirsk