Effect of Native and Modified Apolipoprotein A-I on DNA Synthesis in Cultures of Different Cells
- Авторлар: Usynin I.1, Dudarev A.1, Miroshnichenko S.1, Tkachenko T.1, Gorodetskaya A.1
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Мекемелер:
- Laboratory of Mechanisms of Intercellular Interactions, Research Institute of Biochemistry
- Шығарылым: Том 164, № 2 (2017)
- Беттер: 247-251
- Бөлім: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/239535
- DOI: https://doi.org/10.1007/s10517-017-3967-8
- ID: 239535
Дәйексөз келтіру
Аннотация
Culturing of bone marrow cells in serum-free RPMI-1640 medium for 24 h was accompanied by a decrease in the rate of [3H]-thymidine incorporation into DNA. Addition of native apolipoprotein A-I (apoA-I) or plasma LDL and HDL to the culture medium increased this parameter. In contrast to native apoA-I, its modified form decelerated DNA synthesis in bone marrow cells. A similar inhibitory effect of modified protein was observed in cultures of human embryonic kidney cells (HEK293) and in rapidly proliferating mouse macrophage cell line ANA-1. The only exclusion was human myeloid cell line U937: neither native nor modified apoA-I affected DNA synthesis in these cells. Thus, the regulatory effects of apoA-I are tissue-specific; this protein can produce either stimulatory or inhibitory effect on DNA biosynthesis in cells depending on its conformation.
Авторлар туралы
I. Usynin
Laboratory of Mechanisms of Intercellular Interactions, Research Institute of Biochemistry
Хат алмасуға жауапты Автор.
Email: ivan.usynin@niibch.ru
Ресей, Novosibirsk
A. Dudarev
Laboratory of Mechanisms of Intercellular Interactions, Research Institute of Biochemistry
Email: ivan.usynin@niibch.ru
Ресей, Novosibirsk
S. Miroshnichenko
Laboratory of Mechanisms of Intercellular Interactions, Research Institute of Biochemistry
Email: ivan.usynin@niibch.ru
Ресей, Novosibirsk
T. Tkachenko
Laboratory of Mechanisms of Intercellular Interactions, Research Institute of Biochemistry
Email: ivan.usynin@niibch.ru
Ресей, Novosibirsk
A. Gorodetskaya
Laboratory of Mechanisms of Intercellular Interactions, Research Institute of Biochemistry
Email: ivan.usynin@niibch.ru
Ресей, Novosibirsk