Effects of Tripeptide Gly-His-Lys in Pain-Induced Aggressive-Defensive Behavior in Rats
- Авторлар: Sever’yanova L.1, Dolgintsev M.1
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Мекемелер:
- Department of Pathophysiology, Kursk State Medical University
- Шығарылым: Том 164, № 2 (2017)
- Беттер: 140-143
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239426
- DOI: https://doi.org/10.1007/s10517-017-3943-3
- ID: 239426
Дәйексөз келтіру
Аннотация
We studied the effect of Gly-His -Lys tripeptide administered intraperitoneally in doses of 5, 15, 50 and 150 μg/kg on pain-induced aggressive-defensive behavior. A foot-shock model of aggression in rats grouped in pairs in an electrified chamber was used. Analgesic and antiaggresiogenic effects of the peptide were demonstrated. It was found the L-lysine residue plays the key role in these effects, because they were observed under the influence of L-lysine administration in doses close to its equimolar content in the studied tripeptide.
Авторлар туралы
L. Sever’yanova
Department of Pathophysiology, Kursk State Medical University
Хат алмасуға жауапты Автор.
Email: severlud@yandex.ru
Ресей, Kursk
M. Dolgintsev
Department of Pathophysiology, Kursk State Medical University
Email: severlud@yandex.ru
Ресей, Kursk