Email this article Effects of Tripeptide Gly-His-Lys in Pain-Induced Aggressive-Defensive Behavior in Rats
- Authors: Sever’yanova L.А.1, Dolgintsev M.E.1
-
Affiliations:
- Department of Pathophysiology, Kursk State Medical University
- Issue: Vol 164, No 2 (2017)
- Pages: 140-143
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239426
- DOI: https://doi.org/10.1007/s10517-017-3943-3
- ID: 239426
Cite item
Open Access
Access granted
Subscription Access
Abstract
We studied the effect of Gly-His -Lys tripeptide administered intraperitoneally in doses of 5, 15, 50 and 150 μg/kg on pain-induced aggressive-defensive behavior. A foot-shock model of aggression in rats grouped in pairs in an electrified chamber was used. Analgesic and antiaggresiogenic effects of the peptide were demonstrated. It was found the L-lysine residue plays the key role in these effects, because they were observed under the influence of L-lysine administration in doses close to its equimolar content in the studied tripeptide.
About the authors
L. А. Sever’yanova
Department of Pathophysiology, Kursk State Medical University
Author for correspondence.
Email: severlud@yandex.ru
Russian Federation, Kursk
M. E. Dolgintsev
Department of Pathophysiology, Kursk State Medical University
Email: severlud@yandex.ru
Russian Federation, Kursk
