Role of Glutathione-S-Transferase Family Genes in Male Infertility
- Авторлар: Kolesnikova L.1, Kurashova N.1, Bairova T.1, Dolgikh M.1, Ershova O.1, Dashiev B.2, Korytov L.1, Koroleva N.1
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Мекемелер:
- Research Center of Family Health and Human Reproduction Problems
- Republican Perinatal Center
- Шығарылым: Том 163, № 5 (2017)
- Беттер: 643-645
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239150
- DOI: https://doi.org/10.1007/s10517-017-3869-9
- ID: 239150
Дәйексөз келтіру
Аннотация
Polymorphisms of xenobiotic detoxification genes GSTT1 and GSTM1 and activity of glutathione system enzymes were studied in men with infertility. The frequency of deletion variant of GSTT1 gene in men with infertility was by 2 times higher than in fertile men. Deletion variant of GSTM1 gene was 1.4-fold more frequent in infertile men than in fertile men. Complete deletion of two genes was found in 19% men with infertility and only in 6% fertile men. The balance of activity of glutathione system enzymes essential for the effective detoxification of exogenous xenobiotics and toxic endogenous metabolites was impaired in infertile carriers of deletion variants of genes. Our results suggest that adaptation mechanisms are disordered in infertile men.
Авторлар туралы
L. Kolesnikova
Research Center of Family Health and Human Reproduction Problems
Email: nakurashova@yandex.ru
Ресей, Irkutsk
N. Kurashova
Research Center of Family Health and Human Reproduction Problems
Хат алмасуға жауапты Автор.
Email: nakurashova@yandex.ru
Ресей, Irkutsk
T. Bairova
Research Center of Family Health and Human Reproduction Problems
Email: nakurashova@yandex.ru
Ресей, Irkutsk
M. Dolgikh
Research Center of Family Health and Human Reproduction Problems
Email: nakurashova@yandex.ru
Ресей, Irkutsk
O. Ershova
Research Center of Family Health and Human Reproduction Problems
Email: nakurashova@yandex.ru
Ресей, Irkutsk
B. Dashiev
Republican Perinatal Center
Email: nakurashova@yandex.ru
Ресей, Ulan-Ude, Republic of Buryatia
L. Korytov
Research Center of Family Health and Human Reproduction Problems
Email: nakurashova@yandex.ru
Ресей, Irkutsk
N. Koroleva
Research Center of Family Health and Human Reproduction Problems
Email: nakurashova@yandex.ru
Ресей, Irkutsk