Role of Glutathione-S-Transferase Family Genes in Male Infertility
- Autores: Kolesnikova L.1, Kurashova N.1, Bairova T.1, Dolgikh M.1, Ershova O.1, Dashiev B.2, Korytov L.1, Koroleva N.1
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Afiliações:
- Research Center of Family Health and Human Reproduction Problems
- Republican Perinatal Center
- Edição: Volume 163, Nº 5 (2017)
- Páginas: 643-645
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239150
- DOI: https://doi.org/10.1007/s10517-017-3869-9
- ID: 239150
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Resumo
Polymorphisms of xenobiotic detoxification genes GSTT1 and GSTM1 and activity of glutathione system enzymes were studied in men with infertility. The frequency of deletion variant of GSTT1 gene in men with infertility was by 2 times higher than in fertile men. Deletion variant of GSTM1 gene was 1.4-fold more frequent in infertile men than in fertile men. Complete deletion of two genes was found in 19% men with infertility and only in 6% fertile men. The balance of activity of glutathione system enzymes essential for the effective detoxification of exogenous xenobiotics and toxic endogenous metabolites was impaired in infertile carriers of deletion variants of genes. Our results suggest that adaptation mechanisms are disordered in infertile men.
Sobre autores
L. Kolesnikova
Research Center of Family Health and Human Reproduction Problems
Email: nakurashova@yandex.ru
Rússia, Irkutsk
N. Kurashova
Research Center of Family Health and Human Reproduction Problems
Autor responsável pela correspondência
Email: nakurashova@yandex.ru
Rússia, Irkutsk
T. Bairova
Research Center of Family Health and Human Reproduction Problems
Email: nakurashova@yandex.ru
Rússia, Irkutsk
M. Dolgikh
Research Center of Family Health and Human Reproduction Problems
Email: nakurashova@yandex.ru
Rússia, Irkutsk
O. Ershova
Research Center of Family Health and Human Reproduction Problems
Email: nakurashova@yandex.ru
Rússia, Irkutsk
B. Dashiev
Republican Perinatal Center
Email: nakurashova@yandex.ru
Rússia, Ulan-Ude, Republic of Buryatia
L. Korytov
Research Center of Family Health and Human Reproduction Problems
Email: nakurashova@yandex.ru
Rússia, Irkutsk
N. Koroleva
Research Center of Family Health and Human Reproduction Problems
Email: nakurashova@yandex.ru
Rússia, Irkutsk