Effect of N- and C-Terminal Modifications on Cytotoxic Properties of Antimicrobial Peptide Tachyplesin I
- Авторлар: Kuzmin D.1, Emelianova A.1, Kalashnikova M.1, Panteleev P.1, Ovchinnikova T.1
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Мекемелер:
- M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Шығарылым: Том 162, № 6 (2017)
- Беттер: 754-757
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238528
- DOI: https://doi.org/10.1007/s10517-017-3705-2
- ID: 238528
Дәйексөз келтіру
Аннотация
We analyze the effects of N-terminal acetylation and C-terminal amidation on the cytotoxic properties of β-hairpin antimicrobial peptide tachyplesin I. MTT-assay showed that modified tachyplesin I exhibited increased cytotoxicity toward both tumor and normal human cells. Hemolytic activity of modified tachyplesin I was also higher than that of the initial molecule. In contrast to non-modified tachyplesin I, the peptide with C- and N-terminal modifications is resistant to proteolytic degradation in fresh human serum. C- and N-terminal modifications make tachyplesin I more attractive prototype of anticancer drug due to its more potent cytotoxic effect and better pharmacokinetic properties.
Авторлар туралы
D. Kuzmin
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ovch@ibch.ru
Ресей, Moscow
A. Emelianova
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ovch@ibch.ru
Ресей, Moscow
M. Kalashnikova
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ovch@ibch.ru
Ресей, Moscow
P. Panteleev
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ovch@ibch.ru
Ресей, Moscow
T. Ovchinnikova
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: ovch@ibch.ru
Ресей, Moscow