Effect of N- and C-Terminal Modifications on Cytotoxic Properties of Antimicrobial Peptide Tachyplesin I
- Авторы: Kuzmin D.1, Emelianova A.1, Kalashnikova M.1, Panteleev P.1, Ovchinnikova T.1
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Учреждения:
- M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Выпуск: Том 162, № 6 (2017)
- Страницы: 754-757
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238528
- DOI: https://doi.org/10.1007/s10517-017-3705-2
- ID: 238528
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Аннотация
We analyze the effects of N-terminal acetylation and C-terminal amidation on the cytotoxic properties of β-hairpin antimicrobial peptide tachyplesin I. MTT-assay showed that modified tachyplesin I exhibited increased cytotoxicity toward both tumor and normal human cells. Hemolytic activity of modified tachyplesin I was also higher than that of the initial molecule. In contrast to non-modified tachyplesin I, the peptide with C- and N-terminal modifications is resistant to proteolytic degradation in fresh human serum. C- and N-terminal modifications make tachyplesin I more attractive prototype of anticancer drug due to its more potent cytotoxic effect and better pharmacokinetic properties.
Об авторах
D. Kuzmin
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ovch@ibch.ru
Россия, Moscow
A. Emelianova
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ovch@ibch.ru
Россия, Moscow
M. Kalashnikova
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ovch@ibch.ru
Россия, Moscow
P. Panteleev
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ovch@ibch.ru
Россия, Moscow
T. Ovchinnikova
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: ovch@ibch.ru
Россия, Moscow
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