Oxidative Stress and Biochemical Markers of Endothelial Dysfunction and Organ Damage under Conditions of Experimental Nonferrous Metal Intoxication
- Авторлар: Dzugkoeva F.1, Mozhaeva I.1, Dzugkoev S.1, Margieva O.1, Tedtoeva A.1, Otiev M.1
-
Мекемелер:
- Institute of Biomedical Research, Vladikavkaz Research Center of Russian Academy of Sciences
- Шығарылым: Том 162, № 2 (2016)
- Беттер: 199-202
- Бөлім: Biophysics and Biochemistry
- URL: https://journals.rcsi.science/0007-4888/article/view/238028
- DOI: https://doi.org/10.1007/s10517-016-3575-z
- ID: 238028
Дәйексөз келтіру
Аннотация
Chronic nickel intoxication caused by parenteral nickel chloride administration (0.5 mg/kg of body weight) to Wistar rats led to ROS generation inducing LPO in erythrocyte membranes and homogenates of renal, liver, and myocardial tissue. Superoxide dismutase (SOD) activity was inhibited, while catalase activity and ceruloplasmin concentration increased. LPO and its products disrupted nitric oxide production and reduced its bioavailability, which led to the development of endothelial dysfunction and impaired microcirculatory hemodynamics. At the same time, damage of cytoplasmic membranes of internal organs (kidney, liver, and myocardium) was revealed, which was seen from reduced Na+, K+-ATPase activity in homogenates of these organs and increased serum activity of organ-specific (ALT, AST, and γ-glutamyl transpeptidase) and excretory (alkaline phosphatase) enzymes.
Авторлар туралы
F. Dzugkoeva
Institute of Biomedical Research, Vladikavkaz Research Center of Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: patbiochem@mail.ru
Ресей, Vladikavkaz
I. Mozhaeva
Institute of Biomedical Research, Vladikavkaz Research Center of Russian Academy of Sciences
Email: patbiochem@mail.ru
Ресей, Vladikavkaz
S. Dzugkoev
Institute of Biomedical Research, Vladikavkaz Research Center of Russian Academy of Sciences
Email: patbiochem@mail.ru
Ресей, Vladikavkaz
O. Margieva
Institute of Biomedical Research, Vladikavkaz Research Center of Russian Academy of Sciences
Email: patbiochem@mail.ru
Ресей, Vladikavkaz
A. Tedtoeva
Institute of Biomedical Research, Vladikavkaz Research Center of Russian Academy of Sciences
Email: patbiochem@mail.ru
Ресей, Vladikavkaz
M. Otiev
Institute of Biomedical Research, Vladikavkaz Research Center of Russian Academy of Sciences
Email: patbiochem@mail.ru
Ресей, Vladikavkaz