Oxidative Stress and Biochemical Markers of Endothelial Dysfunction and Organ Damage under Conditions of Experimental Nonferrous Metal Intoxication
- 作者: Dzugkoeva F.1, Mozhaeva I.1, Dzugkoev S.1, Margieva O.1, Tedtoeva A.1, Otiev M.1
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隶属关系:
- Institute of Biomedical Research, Vladikavkaz Research Center of Russian Academy of Sciences
- 期: 卷 162, 编号 2 (2016)
- 页面: 199-202
- 栏目: Biophysics and Biochemistry
- URL: https://journals.rcsi.science/0007-4888/article/view/238028
- DOI: https://doi.org/10.1007/s10517-016-3575-z
- ID: 238028
如何引用文章
详细
Chronic nickel intoxication caused by parenteral nickel chloride administration (0.5 mg/kg of body weight) to Wistar rats led to ROS generation inducing LPO in erythrocyte membranes and homogenates of renal, liver, and myocardial tissue. Superoxide dismutase (SOD) activity was inhibited, while catalase activity and ceruloplasmin concentration increased. LPO and its products disrupted nitric oxide production and reduced its bioavailability, which led to the development of endothelial dysfunction and impaired microcirculatory hemodynamics. At the same time, damage of cytoplasmic membranes of internal organs (kidney, liver, and myocardium) was revealed, which was seen from reduced Na+, K+-ATPase activity in homogenates of these organs and increased serum activity of organ-specific (ALT, AST, and γ-glutamyl transpeptidase) and excretory (alkaline phosphatase) enzymes.
作者简介
F. Dzugkoeva
Institute of Biomedical Research, Vladikavkaz Research Center of Russian Academy of Sciences
编辑信件的主要联系方式.
Email: patbiochem@mail.ru
俄罗斯联邦, Vladikavkaz
I. Mozhaeva
Institute of Biomedical Research, Vladikavkaz Research Center of Russian Academy of Sciences
Email: patbiochem@mail.ru
俄罗斯联邦, Vladikavkaz
S. Dzugkoev
Institute of Biomedical Research, Vladikavkaz Research Center of Russian Academy of Sciences
Email: patbiochem@mail.ru
俄罗斯联邦, Vladikavkaz
O. Margieva
Institute of Biomedical Research, Vladikavkaz Research Center of Russian Academy of Sciences
Email: patbiochem@mail.ru
俄罗斯联邦, Vladikavkaz
A. Tedtoeva
Institute of Biomedical Research, Vladikavkaz Research Center of Russian Academy of Sciences
Email: patbiochem@mail.ru
俄罗斯联邦, Vladikavkaz
M. Otiev
Institute of Biomedical Research, Vladikavkaz Research Center of Russian Academy of Sciences
Email: patbiochem@mail.ru
俄罗斯联邦, Vladikavkaz
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