Evidence of Echocardiography Validity in Model Experiments on Small Animals
- Авторлар: Kryzhanovskii S.1, Kolik L.1, Tsorin I.1, Ionova E.1, Stolyaruk V.1, Sorokina A.1, Vititnova M.1, Miroshkina I.1
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Мекемелер:
- V. V. Zakusov Research Institute of Pharmacology
- Шығарылым: Том 161, № 3 (2016)
- Беттер: 434-438
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237491
- DOI: https://doi.org/10.1007/s10517-016-3432-0
- ID: 237491
Дәйексөз келтіру
Аннотация
Dynamic echocardiographic monitoring in rats subjected to forced alcoholization showed the formation of disorders in intracardiac hemodynamics characteristic of ethanol cardiomyopathy formed by the end of 24-week continuous ethanol consumption. The results of echocardiographic monitoring were confirmed by histological and morphometric studies demonstrating fatty infiltration of the myocardium pathognomonic for this condition and bifocal dilatation of cardiac ventricles. These results persuasively demonstrate that echocardiographic studies on small animals are valid and can be used for search for cardiotropic drugs and studies of the mechanisms of their activities.
Авторлар туралы
S. Kryzhanovskii
V. V. Zakusov Research Institute of Pharmacology
Хат алмасуға жауапты Автор.
Email: SAK-538@yandex.ru
Ресей, Moscow
L. Kolik
V. V. Zakusov Research Institute of Pharmacology
Email: SAK-538@yandex.ru
Ресей, Moscow
I. Tsorin
V. V. Zakusov Research Institute of Pharmacology
Email: SAK-538@yandex.ru
Ресей, Moscow
E. Ionova
V. V. Zakusov Research Institute of Pharmacology
Email: SAK-538@yandex.ru
Ресей, Moscow
V. Stolyaruk
V. V. Zakusov Research Institute of Pharmacology
Email: SAK-538@yandex.ru
Ресей, Moscow
A. Sorokina
V. V. Zakusov Research Institute of Pharmacology
Email: SAK-538@yandex.ru
Ресей, Moscow
M. Vititnova
V. V. Zakusov Research Institute of Pharmacology
Email: SAK-538@yandex.ru
Ресей, Moscow
I. Miroshkina
V. V. Zakusov Research Institute of Pharmacology
Email: SAK-538@yandex.ru
Ресей, Moscow
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