Transport and Toxicity of Silver Nanoparticles in HepaRG Cell Spheroids
- Авторлар: Senyavina N.1, Gerasimenko T.1, Pulkova N.1, Maltseva D.1
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Мекемелер:
- BioClinicum Research and Development Center
- Шығарылым: Том 160, № 6 (2016)
- Беттер: 831-834
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236986
- DOI: https://doi.org/10.1007/s10517-016-3321-6
- ID: 236986
Дәйексөз келтіру
Аннотация
We studied the effects of silver nanoparticles (10 nm) on HepaRG cell spheroids simulating liver tissue. The mathematical model was proposed that describes nanoparticle diffusion in a spheroid consisting of 5000 cells depending on the external nanoparticle concentration. It was demonstrated that cells in the 3D model were less sensitive to the toxic effects of nanoparticles in comparison with 2D cultures. Impaired integrity of the cell membrane did not deteriorate cell viability (according to MTT test).
Авторлар туралы
N. Senyavina
BioClinicum Research and Development Center
Хат алмасуға жауапты Автор.
Email: n.seniavona@bioclinicum.com
Ресей, Moscow
T. Gerasimenko
BioClinicum Research and Development Center
Email: n.seniavona@bioclinicum.com
Ресей, Moscow
N. Pulkova
BioClinicum Research and Development Center
Email: n.seniavona@bioclinicum.com
Ресей, Moscow
D. Maltseva
BioClinicum Research and Development Center
Email: n.seniavona@bioclinicum.com
Ресей, Moscow
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