Transport and Toxicity of Silver Nanoparticles in HepaRG Cell Spheroids
- 作者: Senyavina N.1, Gerasimenko T.1, Pulkova N.1, Maltseva D.1
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隶属关系:
- BioClinicum Research and Development Center
- 期: 卷 160, 编号 6 (2016)
- 页面: 831-834
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236986
- DOI: https://doi.org/10.1007/s10517-016-3321-6
- ID: 236986
如何引用文章
详细
We studied the effects of silver nanoparticles (10 nm) on HepaRG cell spheroids simulating liver tissue. The mathematical model was proposed that describes nanoparticle diffusion in a spheroid consisting of 5000 cells depending on the external nanoparticle concentration. It was demonstrated that cells in the 3D model were less sensitive to the toxic effects of nanoparticles in comparison with 2D cultures. Impaired integrity of the cell membrane did not deteriorate cell viability (according to MTT test).
作者简介
N. Senyavina
BioClinicum Research and Development Center
编辑信件的主要联系方式.
Email: n.seniavona@bioclinicum.com
俄罗斯联邦, Moscow
T. Gerasimenko
BioClinicum Research and Development Center
Email: n.seniavona@bioclinicum.com
俄罗斯联邦, Moscow
N. Pulkova
BioClinicum Research and Development Center
Email: n.seniavona@bioclinicum.com
俄罗斯联邦, Moscow
D. Maltseva
BioClinicum Research and Development Center
Email: n.seniavona@bioclinicum.com
俄罗斯联邦, Moscow
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