Effect of a New Antioxidant Enoxifol on Platelet Aggregation and Blood Rheological Properties in Rats with Experimental Diabetes Mellitus
- Авторлар: Kucheryavenko A.1, Spasov A.1, Anisimova V.2
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Мекемелер:
- Department of Pharmacology, Volgograd State Medical University
- Research Institute of Physical and Organic Chemistry, Southern Federal University
- Шығарылым: Том 160, № 6 (2016)
- Беттер: 759-762
- Бөлім: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/236931
- DOI: https://doi.org/10.1007/s10517-016-3303-8
- ID: 236931
Дәйексөз келтіру
Аннотация
Effect of a new antioxidant enoxifol exhibiting antiplatelet activity in vitro and in vivo on hemostasis parameters was assessed in laboratory rats with experimental diabetes mellitus. Gliclazide, a hypoglycemic agent with antiplatelet properties, and pentoxifylline, a preparation improving blood rheology, were used as the reference drugs. Enoxifol produced a pronounced inhibitory effect on platelet aggregation in rats with experimental diabetes comparable to the effect of gliclazide and decreased blood viscosity thus demonstrating a significant effect comparable to that of pentoxifylline. In view of the fact that oxidative stress is a pathogenetic components of vascular complications in diabetes, it can be assumed that improvement of hemostasis parameters under the effect of enoxifol is determined by its antiplatelet and antioxidant activities.
Авторлар туралы
A. Kucheryavenko
Department of Pharmacology, Volgograd State Medical University
Хат алмасуға жауапты Автор.
Email: aidakucheryavenko@yandex.ru
Ресей, Volgograd
A. Spasov
Department of Pharmacology, Volgograd State Medical University
Email: aidakucheryavenko@yandex.ru
Ресей, Volgograd
V. Anisimova
Research Institute of Physical and Organic Chemistry, Southern Federal University
Email: aidakucheryavenko@yandex.ru
Ресей, Rostov-on-Don
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