Effect of a New Antioxidant Enoxifol on Platelet Aggregation and Blood Rheological Properties in Rats with Experimental Diabetes Mellitus
- Authors: Kucheryavenko A.F.1, Spasov A.A.1, Anisimova V.A.2
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Affiliations:
- Department of Pharmacology, Volgograd State Medical University
- Research Institute of Physical and Organic Chemistry, Southern Federal University
- Issue: Vol 160, No 6 (2016)
- Pages: 759-762
- Section: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/236931
- DOI: https://doi.org/10.1007/s10517-016-3303-8
- ID: 236931
Cite item
Abstract
Effect of a new antioxidant enoxifol exhibiting antiplatelet activity in vitro and in vivo on hemostasis parameters was assessed in laboratory rats with experimental diabetes mellitus. Gliclazide, a hypoglycemic agent with antiplatelet properties, and pentoxifylline, a preparation improving blood rheology, were used as the reference drugs. Enoxifol produced a pronounced inhibitory effect on platelet aggregation in rats with experimental diabetes comparable to the effect of gliclazide and decreased blood viscosity thus demonstrating a significant effect comparable to that of pentoxifylline. In view of the fact that oxidative stress is a pathogenetic components of vascular complications in diabetes, it can be assumed that improvement of hemostasis parameters under the effect of enoxifol is determined by its antiplatelet and antioxidant activities.
About the authors
A. F. Kucheryavenko
Department of Pharmacology, Volgograd State Medical University
Author for correspondence.
Email: aidakucheryavenko@yandex.ru
Russian Federation, Volgograd
A. A. Spasov
Department of Pharmacology, Volgograd State Medical University
Email: aidakucheryavenko@yandex.ru
Russian Federation, Volgograd
V. A. Anisimova
Research Institute of Physical and Organic Chemistry, Southern Federal University
Email: aidakucheryavenko@yandex.ru
Russian Federation, Rostov-on-Don
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