Protection of Neurovascular Unit Cells with Lithium Chloride and Sodium Valproate Prevents Brain Damage in Neonatal Ischemia/Hypoxia
- Авторлар: Silachev D.1, Plotnikov E.1, Babenko V.2,3, Savchenko E.2, Zorova L.4, Pevzner I.1, Gulyaev M.5, Pirogov Y.5, Sukhikh G.3, Zorov D.1
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Мекемелер:
- A. N. Belozersky Institute of Physical and Chemical Biology
- Faculty of Bioengineering and Bioinformatics
- V. I. Kulakov Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
- International Laser Research Centre, M. V. Lomonosov Moscow State University
- Faculty of Physics, M. V. Lomonosov Moscow State University
- Шығарылым: Том 160, № 3 (2016)
- Беттер: 313-318
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236695
- DOI: https://doi.org/10.1007/s10517-016-3159-y
- ID: 236695
Дәйексөз келтіру
Аннотация
Here we studied the cytoprotective effect of lithium chloride and sodium valproate in the in vivo model of neonatal cerebral ischemia/hypoxia and analyzed the influence of these substances on the death of the major neurovascular unit components in experimental ischemia in vitro. Lithium chloride and sodium valproate effectively prevented death of neurons, astrocytes, and endothelial cells in the oxygen-glucose deprivation. This treatment protected the brain of newborn rats from ischemia/hypoxia injury. The results suggest that lithium and sodium valproate can be used for the treatment of neurodegenerative pathologies associated with hypoxia and ischemia in newborns.
Авторлар туралы
D. Silachev
A. N. Belozersky Institute of Physical and Chemical Biology
Email: zorov@genebee.msu.ru
Ресей, Moscow
E. Plotnikov
A. N. Belozersky Institute of Physical and Chemical Biology
Email: zorov@genebee.msu.ru
Ресей, Moscow
V. Babenko
Faculty of Bioengineering and Bioinformatics; V. I. Kulakov Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: zorov@genebee.msu.ru
Ресей, Moscow; Moscow
E. Savchenko
Faculty of Bioengineering and Bioinformatics
Email: zorov@genebee.msu.ru
Ресей, Moscow
L. Zorova
International Laser Research Centre, M. V. Lomonosov Moscow State University
Email: zorov@genebee.msu.ru
Ресей, Moscow
I. Pevzner
A. N. Belozersky Institute of Physical and Chemical Biology
Email: zorov@genebee.msu.ru
Ресей, Moscow
M. Gulyaev
Faculty of Physics, M. V. Lomonosov Moscow State University
Email: zorov@genebee.msu.ru
Ресей, Moscow
Yu. Pirogov
Faculty of Physics, M. V. Lomonosov Moscow State University
Email: zorov@genebee.msu.ru
Ресей, Moscow
G. Sukhikh
V. I. Kulakov Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: zorov@genebee.msu.ru
Ресей, Moscow
D. Zorov
A. N. Belozersky Institute of Physical and Chemical Biology
Хат алмасуға жауапты Автор.
Email: zorov@genebee.msu.ru
Ресей, Moscow
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