Protection of Neurovascular Unit Cells with Lithium Chloride and Sodium Valproate Prevents Brain Damage in Neonatal Ischemia/Hypoxia
- Authors: Silachev D.N.1, Plotnikov E.Y.1, Babenko V.A.2,3, Savchenko E.S.2, Zorova L.D.4, Pevzner I.B.1, Gulyaev M.V.5, Pirogov Y.A.5, Sukhikh G.T.3, Zorov D.B.1
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Affiliations:
- A. N. Belozersky Institute of Physical and Chemical Biology
- Faculty of Bioengineering and Bioinformatics
- V. I. Kulakov Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
- International Laser Research Centre, M. V. Lomonosov Moscow State University
- Faculty of Physics, M. V. Lomonosov Moscow State University
- Issue: Vol 160, No 3 (2016)
- Pages: 313-318
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236695
- DOI: https://doi.org/10.1007/s10517-016-3159-y
- ID: 236695
Cite item
Abstract
Here we studied the cytoprotective effect of lithium chloride and sodium valproate in the in vivo model of neonatal cerebral ischemia/hypoxia and analyzed the influence of these substances on the death of the major neurovascular unit components in experimental ischemia in vitro. Lithium chloride and sodium valproate effectively prevented death of neurons, astrocytes, and endothelial cells in the oxygen-glucose deprivation. This treatment protected the brain of newborn rats from ischemia/hypoxia injury. The results suggest that lithium and sodium valproate can be used for the treatment of neurodegenerative pathologies associated with hypoxia and ischemia in newborns.
About the authors
D. N. Silachev
A. N. Belozersky Institute of Physical and Chemical Biology
Email: zorov@genebee.msu.ru
Russian Federation, Moscow
E. Yu. Plotnikov
A. N. Belozersky Institute of Physical and Chemical Biology
Email: zorov@genebee.msu.ru
Russian Federation, Moscow
V. A. Babenko
Faculty of Bioengineering and Bioinformatics; V. I. Kulakov Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: zorov@genebee.msu.ru
Russian Federation, Moscow; Moscow
E. S. Savchenko
Faculty of Bioengineering and Bioinformatics
Email: zorov@genebee.msu.ru
Russian Federation, Moscow
L. D. Zorova
International Laser Research Centre, M. V. Lomonosov Moscow State University
Email: zorov@genebee.msu.ru
Russian Federation, Moscow
I. B. Pevzner
A. N. Belozersky Institute of Physical and Chemical Biology
Email: zorov@genebee.msu.ru
Russian Federation, Moscow
M. V. Gulyaev
Faculty of Physics, M. V. Lomonosov Moscow State University
Email: zorov@genebee.msu.ru
Russian Federation, Moscow
Yu. A. Pirogov
Faculty of Physics, M. V. Lomonosov Moscow State University
Email: zorov@genebee.msu.ru
Russian Federation, Moscow
G. T. Sukhikh
V. I. Kulakov Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: zorov@genebee.msu.ru
Russian Federation, Moscow
D. B. Zorov
A. N. Belozersky Institute of Physical and Chemical Biology
Author for correspondence.
Email: zorov@genebee.msu.ru
Russian Federation, Moscow