A Translational Model of Chronic Heart Failure
- Authors: Kryzhanovskii S.A.1, Tsorin I.B.1, Stolyaruk V.N.1, Vititnova M.B.1, Ionova E.O.1, Barchukov V.V.1, Miroshkina I.A.1, Sorokina A.V.1, Kozhevnikova L.M.1, Durnev A.D.1
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Affiliations:
- V. V. Zakusov Research Institute of Pharmacology
- Issue: Vol 167, No 5 (2019)
- Pages: 706-710
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/242051
- DOI: https://doi.org/10.1007/s10517-019-04604-y
- ID: 242051
Cite item
Abstract
We created a translational model of chronic heart failure in rats that developed in 3 months after reproducing experimental anterior transmural myocardial infarction. The model simulated the basic clinicodiagnostic criteria of this disease: impaired contractility and dilatation of heart ventricles, signs of venous congestion, elevated plasma content of biochemical markers, and abnormal overexpression of AT1aR and β-adrenoceptors.
About the authors
S. A. Kryzhanovskii
V. V. Zakusov Research Institute of Pharmacology
Author for correspondence.
Email: sak_538@yandex.ru
Russian Federation, Moscow
I. B. Tsorin
V. V. Zakusov Research Institute of Pharmacology
Email: sak_538@yandex.ru
Russian Federation, Moscow
V. N. Stolyaruk
V. V. Zakusov Research Institute of Pharmacology
Email: sak_538@yandex.ru
Russian Federation, Moscow
M. B. Vititnova
V. V. Zakusov Research Institute of Pharmacology
Email: sak_538@yandex.ru
Russian Federation, Moscow
E. O. Ionova
V. V. Zakusov Research Institute of Pharmacology
Email: sak_538@yandex.ru
Russian Federation, Moscow
V. V. Barchukov
V. V. Zakusov Research Institute of Pharmacology
Email: sak_538@yandex.ru
Russian Federation, Moscow
I. A. Miroshkina
V. V. Zakusov Research Institute of Pharmacology
Email: sak_538@yandex.ru
Russian Federation, Moscow
A. V. Sorokina
V. V. Zakusov Research Institute of Pharmacology
Email: sak_538@yandex.ru
Russian Federation, Moscow
L. M. Kozhevnikova
V. V. Zakusov Research Institute of Pharmacology
Email: sak_538@yandex.ru
Russian Federation, Moscow
A. D. Durnev
V. V. Zakusov Research Institute of Pharmacology
Email: sak_538@yandex.ru
Russian Federation, Moscow