A Translational Model of Chronic Heart Failure

S. A. Kryzhanovskii; I. B. Tsorin; V. N. Stolyaruk; M. B. Vititnova; E. O. Ionova; V. V. Barchukov; I. A. Miroshkina; A. V. Sorokina; L. M. Kozhevnikova; A. D. Durnev

doi:10.1007/s10517-019-04604-y

A Translational Model of Chronic Heart Failure

Authors: Kryzhanovskii S.A.¹, Tsorin I.B.¹, Stolyaruk V.N.¹, Vititnova M.B.¹, Ionova E.O.¹, Barchukov V.V.¹, Miroshkina I.A.¹, Sorokina A.V.¹, Kozhevnikova L.M.¹, Durnev A.D.¹
Affiliations:
1. V. V. Zakusov Research Institute of Pharmacology
Issue: Vol 167, No 5 (2019)
Pages: 706-710
Section: Article
URL: https://journals.rcsi.science/0007-4888/article/view/242051
DOI: https://doi.org/10.1007/s10517-019-04604-y
ID: 242051

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Abstract

We created a translational model of chronic heart failure in rats that developed in 3 months after reproducing experimental anterior transmural myocardial infarction. The model simulated the basic clinicodiagnostic criteria of this disease: impaired contractility and dilatation of heart ventricles, signs of venous congestion, elevated plasma content of biochemical markers, and abnormal overexpression of AT1aR and β-adrenoceptors.