Reaction of Mast Cells in the Zone of Polypropylene Mesh Implantation
- Authors: Grigoryuk A.A.1, Belov S.A.2, Kotsyuba A.E.1
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Affiliations:
- Pacific State Medical University
- Primorye Territorial Tuberculosis Control Center
- Issue: Vol 167, No 5 (2019)
- Pages: 694-697
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/242029
- DOI: https://doi.org/10.1007/s10517-019-04601-1
- ID: 242029
Cite item
Abstract
Reaction of mast cells of adult male Wistar rats (n=15) in the zone of polypropylene mesh fixation was studied by histochemical, immunohistochemical, and traditional morphological methods on days 1, 5, 10, and 30 after implantation. Immediately after the intervention, mast cells stimulated the processes aimed at wound healing. Secretion of mast cells was clearly regulatory. These cells migrated to the zone of injury for subsequent activation of their function. The number of cNOS+ mast cells near the polypropylene mesh was maximum on day 1 and the number of iNOS+ mast cells peaked on day 5 of the experiment, which probably represented a compensatory reaction. Presumably, stimulation of fibrillogenesis was largely due to the activatory effect of mast cells on the fibroblast function, but not to collagen production by these mast cells.
About the authors
A. A. Grigoryuk
Pacific State Medical University
Author for correspondence.
Email: aa_grig@mail.ru
Russian Federation, Vladivostok
S. A. Belov
Primorye Territorial Tuberculosis Control Center
Email: aa_grig@mail.ru
Russian Federation, Vladivostok
A. E. Kotsyuba
Pacific State Medical University
Email: aa_grig@mail.ru
Russian Federation, Vladivostok