Age-Dependent Effects of NO on Rhythmic Activity of Postganglionic Sympathetic Fibers
- Authors: Moiseev K.Y.1, Verbovetskaya A.I.1, Maslyukov A.P.1, Maslyukov P.M.1
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Affiliations:
- Yaroslavl State Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 167, No 2 (2019)
- Pages: 191-193
- Section: Physiology
- URL: https://journals.rcsi.science/0007-4888/article/view/241576
- DOI: https://doi.org/10.1007/s10517-019-04488-y
- ID: 241576
Cite item
Abstract
We studied the effects of exogenous NO donor (sodium nitroprusside) and NO synthesis blocker (100 μM L-NAME) on baseline electrical activity of postganglionic fibers in the sympathetic superior cervical in rats during postnatal ontogeny. Starting the age of 20 days, sodium nitroprusside increased the mean discharge amplitude and the spectrum power in the respiratory (0.7-1.5 Hz) and cardiac (4-7 Hz) frequency bands. In contrast, application of L-NAME for 1 h decreased the spectrum power in these bands. Both agents produced no significant effect on the rhythmic sympathetic discharges at frequencies >8 Hz.
About the authors
K. Yu. Moiseev
Yaroslavl State Medical University, Ministry of Health of the Russian Federation
Email: mpm@ysmu.ru
Russian Federation, Yaroslavl
A. I. Verbovetskaya
Yaroslavl State Medical University, Ministry of Health of the Russian Federation
Email: mpm@ysmu.ru
Russian Federation, Yaroslavl
A. P. Maslyukov
Yaroslavl State Medical University, Ministry of Health of the Russian Federation
Email: mpm@ysmu.ru
Russian Federation, Yaroslavl
P. M. Maslyukov
Yaroslavl State Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: mpm@ysmu.ru
Russian Federation, Yaroslavl