Comparison of Biological Effects of γ-Radiation of Low and Ultra-High Dose Rate on Lymphocytes and Cultured Human Malignant Lymphoma Cells
- Authors: Bozhenko V.K.1, Ivanov A.V.1, Kulinich T.M.1, Smirnov V.P.1, Shishkin A.M.1, Solodky V.A.1
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Affiliations:
- Russian Scientific Center of Roentgenoradiology, Ministry of Health of the Russian Federation
- Issue: Vol 166, No 6 (2019)
- Pages: 785-787
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241364
- DOI: https://doi.org/10.1007/s10517-019-04440-0
- ID: 241364
Cite item
Abstract
We studied the effect of low and high-dose rate photon radiation on activation of cell death by apoptosis and necrosis in malignant cell lines of lymphocytic origin Raji and Jurkat (human B and T-cell lymphomas) and normal human lymphocytes from healthy volunteers. It was shown that photon radiation with ultra-high dose rate induced significantly higher levels of “early” apoptosis and lower levels of necrosis compared to γ-radiation with dose rate used for radiation therapy.
About the authors
V. K. Bozhenko
Russian Scientific Center of Roentgenoradiology, Ministry of Health of the Russian Federation
Author for correspondence.
Email: vbojenko@mail.ru
Russian Federation, Moscow
A. V. Ivanov
Russian Scientific Center of Roentgenoradiology, Ministry of Health of the Russian Federation
Email: vbojenko@mail.ru
Russian Federation, Moscow
T. M. Kulinich
Russian Scientific Center of Roentgenoradiology, Ministry of Health of the Russian Federation
Email: vbojenko@mail.ru
Russian Federation, Moscow
V. P. Smirnov
Russian Scientific Center of Roentgenoradiology, Ministry of Health of the Russian Federation
Email: vbojenko@mail.ru
Russian Federation, Moscow
A. M. Shishkin
Russian Scientific Center of Roentgenoradiology, Ministry of Health of the Russian Federation
Email: vbojenko@mail.ru
Russian Federation, Moscow
V. A. Solodky
Russian Scientific Center of Roentgenoradiology, Ministry of Health of the Russian Federation
Email: vbojenko@mail.ru
Russian Federation, Moscow