Comparison of Biological Effects of γ-Radiation of Low and Ultra-High Dose Rate on Lymphocytes and Cultured Human Malignant Lymphoma Cells

V. K. Bozhenko; A. V. Ivanov; T. M. Kulinich; V. P. Smirnov; A. M. Shishkin; V. A. Solodky

doi:10.1007/s10517-019-04440-0

Comparison of Biological Effects of γ-Radiation of Low and Ultra-High Dose Rate on Lymphocytes and Cultured Human Malignant Lymphoma Cells

Authors: Bozhenko V.K.¹, Ivanov A.V.¹, Kulinich T.M.¹, Smirnov V.P.¹, Shishkin A.M.¹, Solodky V.A.¹
Affiliations:
1. Russian Scientific Center of Roentgenoradiology, Ministry of Health of the Russian Federation
Issue: Vol 166, No 6 (2019)
Pages: 785-787
Section: Article
URL: https://journals.rcsi.science/0007-4888/article/view/241364
DOI: https://doi.org/10.1007/s10517-019-04440-0
ID: 241364

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Abstract

We studied the effect of low and high-dose rate photon radiation on activation of cell death by apoptosis and necrosis in malignant cell lines of lymphocytic origin Raji and Jurkat (human B and T-cell lymphomas) and normal human lymphocytes from healthy volunteers. It was shown that photon radiation with ultra-high dose rate induced significantly higher levels of “early” apoptosis and lower levels of necrosis compared to γ-radiation with dose rate used for radiation therapy.