Ergoferon Increases IL-2 Production by Activated Lymphocytes
- Authors: Kanareikina M.A.1, Alinkina E.S.1, Petrova A.O.1, Emel’yanova A.G.1, Gorbunov E.A.1, Tarasov S.A.2
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Affiliations:
- Materia Medica Holding Research-and-Production Company, Research Institute of General Pathology and Pathophysiology
- Laboratory of Physiologically Active Substances, Department of Molecular and Cellular Pathophysiology, Research Institute of General Pathology and Pathophysiology
- Issue: Vol 166, No 6 (2019)
- Pages: 744-746
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241330
- DOI: https://doi.org/10.1007/s10517-019-04431-1
- ID: 241330
Cite item
Abstract
We studied the effects of Ergoferon on the production of antiviral cytokine IL-2 by type 1 CD4+T cells. Preincubation of Jurkat cells with Ergoferon increased IL-2 secretion by these cells after stimulation with phorbol 12-myristate 13-acetate/ionomycine in comparison with the placebo group. The data prove that Ergoferon is capable of activating cell cascades involved in the realization of the antiviral immune response.
About the authors
M. A. Kanareikina
Materia Medica Holding Research-and-Production Company, Research Institute of General Pathology and Pathophysiology
Author for correspondence.
Email: rad@materiamedica.ru
Russian Federation, Moscow
E. S. Alinkina
Materia Medica Holding Research-and-Production Company, Research Institute of General Pathology and Pathophysiology
Email: rad@materiamedica.ru
Russian Federation, Moscow
A. O. Petrova
Materia Medica Holding Research-and-Production Company, Research Institute of General Pathology and Pathophysiology
Email: rad@materiamedica.ru
Russian Federation, Moscow
A. G. Emel’yanova
Materia Medica Holding Research-and-Production Company, Research Institute of General Pathology and Pathophysiology
Email: rad@materiamedica.ru
Russian Federation, Moscow
E. A. Gorbunov
Materia Medica Holding Research-and-Production Company, Research Institute of General Pathology and Pathophysiology
Email: rad@materiamedica.ru
Russian Federation, Moscow
S. A. Tarasov
Laboratory of Physiologically Active Substances, Department of Molecular and Cellular Pathophysiology, Research Institute of General Pathology and Pathophysiology
Email: rad@materiamedica.ru
Russian Federation, Moscow