Ergoferon Increases IL-2 Production by Activated Lymphocytes

M. A. Kanareikina; E. S. Alinkina; A. O. Petrova; A. G. Emel’yanova; E. A. Gorbunov; S. A. Tarasov

doi:10.1007/s10517-019-04431-1

Ergoferon Increases IL-2 Production by Activated Lymphocytes

Authors: Kanareikina M.A.¹, Alinkina E.S.¹, Petrova A.O.¹, Emel’yanova A.G.¹, Gorbunov E.A.¹, Tarasov S.A.²
Affiliations:
1. Materia Medica Holding Research-and-Production Company, Research Institute of General Pathology and Pathophysiology
2. Laboratory of Physiologically Active Substances, Department of Molecular and Cellular Pathophysiology, Research Institute of General Pathology and Pathophysiology
Issue: Vol 166, No 6 (2019)
Pages: 744-746
Section: Article
URL: https://journals.rcsi.science/0007-4888/article/view/241330
DOI: https://doi.org/10.1007/s10517-019-04431-1
ID: 241330

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Abstract

We studied the effects of Ergoferon on the production of antiviral cytokine IL-2 by type 1 CD4⁺T cells. Preincubation of Jurkat cells with Ergoferon increased IL-2 secretion by these cells after stimulation with phorbol 12-myristate 13-acetate/ionomycine in comparison with the placebo group. The data prove that Ergoferon is capable of activating cell cascades involved in the realization of the antiviral immune response.