Metabolism of a Novel Anxiolytic GML-1 in Rats
- Authors: Novitskii A.A.1, Bochkov P.O.1, Shevchenko R.V.1, Gribakina O.G.1, Litvin A.A.1, Kolyvanov G.B.1, Zherdev V.P.1
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Affiliations:
- Laboratory of Pharmacokinetics, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences
- Issue: Vol 165, No 6 (2018)
- Pages: 751-753
- Section: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/240721
- DOI: https://doi.org/10.1007/s10517-018-4257-9
- ID: 240721
Cite item
Abstract
Metabolism of a novel anxiolytic GML-1 (N-benzyl-N-methyl-1-phenylpyrrolo[1,2-a]pirazin-3-carboxamide) in rat blood plasma was studied by HPLC-mass spectrometry. Three biotransformation products with the corresponding molecular ions were detected. A conclusion was made that the main pathways of GML-1 metabolism are oxidative reactions yielding hydroxylated, methylated, and demethylated metabolites.
About the authors
A. A. Novitskii
Laboratory of Pharmacokinetics, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences
Email: litbiopharm@yandex.ru
Russian Federation, Moscow
P. O. Bochkov
Laboratory of Pharmacokinetics, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences
Email: litbiopharm@yandex.ru
Russian Federation, Moscow
R. V. Shevchenko
Laboratory of Pharmacokinetics, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences
Email: litbiopharm@yandex.ru
Russian Federation, Moscow
O. G. Gribakina
Laboratory of Pharmacokinetics, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences
Email: litbiopharm@yandex.ru
Russian Federation, Moscow
A. A. Litvin
Laboratory of Pharmacokinetics, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences
Author for correspondence.
Email: litbiopharm@yandex.ru
Russian Federation, Moscow
G. B. Kolyvanov
Laboratory of Pharmacokinetics, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences
Email: litbiopharm@yandex.ru
Russian Federation, Moscow
V. P. Zherdev
Laboratory of Pharmacokinetics, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences
Email: litbiopharm@yandex.ru
Russian Federation, Moscow