Metabolism of a Novel Anxiolytic GML-1 in Rats
- Autores: Novitskii A.1, Bochkov P.1, Shevchenko R.1, Gribakina O.1, Litvin A.1, Kolyvanov G.1, Zherdev V.1
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Afiliações:
- Laboratory of Pharmacokinetics, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences
- Edição: Volume 165, Nº 6 (2018)
- Páginas: 751-753
- Seção: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/240721
- DOI: https://doi.org/10.1007/s10517-018-4257-9
- ID: 240721
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Resumo
Metabolism of a novel anxiolytic GML-1 (N-benzyl-N-methyl-1-phenylpyrrolo[1,2-a]pirazin-3-carboxamide) in rat blood plasma was studied by HPLC-mass spectrometry. Three biotransformation products with the corresponding molecular ions were detected. A conclusion was made that the main pathways of GML-1 metabolism are oxidative reactions yielding hydroxylated, methylated, and demethylated metabolites.
Sobre autores
A. Novitskii
Laboratory of Pharmacokinetics, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences
Email: litbiopharm@yandex.ru
Rússia, Moscow
P. Bochkov
Laboratory of Pharmacokinetics, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences
Email: litbiopharm@yandex.ru
Rússia, Moscow
R. Shevchenko
Laboratory of Pharmacokinetics, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences
Email: litbiopharm@yandex.ru
Rússia, Moscow
O. Gribakina
Laboratory of Pharmacokinetics, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences
Email: litbiopharm@yandex.ru
Rússia, Moscow
A. Litvin
Laboratory of Pharmacokinetics, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences
Autor responsável pela correspondência
Email: litbiopharm@yandex.ru
Rússia, Moscow
G. Kolyvanov
Laboratory of Pharmacokinetics, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences
Email: litbiopharm@yandex.ru
Rússia, Moscow
V. Zherdev
Laboratory of Pharmacokinetics, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences
Email: litbiopharm@yandex.ru
Rússia, Moscow