Functional Connectivity of Brain Regions According to Resting State fMRI: Differences between Healthy and Depressed Subjects and Variability of the Results
- Authors: Bezmaternykh D.D.1,2, Mel’nikov M.E.1,2, Kozlova L.I.1,2, Shtark M.B.1,2, Savelov A.A.3, Petrovskii E.D.3, Shubina O.S.1, Natarova K.A.4
-
Affiliations:
- Research Institute of Molecular Biology and Biophysics
- Novosibirsk National Research State University
- International Tomography Center, Siberian Division of the Russian Academy of Sciences
- International Institute of Psychology and Psychotherapy
- Issue: Vol 165, No 6 (2018)
- Pages: 734-740
- Section: Biophysics and Biochemistry
- URL: https://journals.rcsi.science/0007-4888/article/view/240715
- DOI: https://doi.org/10.1007/s10517-018-4254-z
- ID: 240715
Cite item
Abstract
In depressed patients, changes in spontaneous brain activity, in particular, the strength of functional connectivity between different regions are observed. The data on changes in the synchrony of different regions of interest in the brain can serve as markers of depressive symptoms and as the targets for the corresponding therapy. The study involved 21 patients with mild depression and 21 healthy volunteers; by the time of second fMRI scanning, 15 and 19 subjects, respectively). The subjects underwent two 4-min sessions of resting state fMRI with 2-4 months interval between the recordings; on the basis of these data, functional connectivity between regions of interest was assessed. During the first session, depressed patients demonstrated more pronounced connection between the right frontal eye field and cerebellar area III. When the sample was restricted to subjects who underwent both fMRI sessions, depressed patients demonstrated closer relations of the right parietal operculum and cerebellar vermis area VIII. During the second recording, healthy subjects showed stronger connectivity between more than 20 frontal, temporal, and subcortical regions of interest and cerebellum area II. In healthy participants, brainstem functional interactions increased from the first to the second fMRI-recording. In depressed subjects a number of cortical areas split from left intraparietal sulcus, but the left temporal cortex became more intra-connected. The results confirm the differences in functional connectivity between depressed and healthy subjects. At the same time, attention should be paid to the variability of the data obtained.
About the authors
D. D. Bezmaternykh
Research Institute of Molecular Biology and Biophysics; Novosibirsk National Research State University
Email: mikhail-melnikov@mail.ru
Russian Federation, Novosibirsk; Novosibirsk
M. E. Mel’nikov
Research Institute of Molecular Biology and Biophysics; Novosibirsk National Research State University
Author for correspondence.
Email: mikhail-melnikov@mail.ru
Russian Federation, Novosibirsk; Novosibirsk
L. I. Kozlova
Research Institute of Molecular Biology and Biophysics; Novosibirsk National Research State University
Email: mikhail-melnikov@mail.ru
Russian Federation, Novosibirsk; Novosibirsk
M. B. Shtark
Research Institute of Molecular Biology and Biophysics; Novosibirsk National Research State University
Email: mikhail-melnikov@mail.ru
Russian Federation, Novosibirsk; Novosibirsk
A. A. Savelov
International Tomography Center, Siberian Division of the Russian Academy of Sciences
Email: mikhail-melnikov@mail.ru
Russian Federation, Novosibirsk
E. D. Petrovskii
International Tomography Center, Siberian Division of the Russian Academy of Sciences
Email: mikhail-melnikov@mail.ru
Russian Federation, Novosibirsk
O. S. Shubina
Research Institute of Molecular Biology and Biophysics
Email: mikhail-melnikov@mail.ru
Russian Federation, Novosibirsk
K. A. Natarova
International Institute of Psychology and Psychotherapy
Email: mikhail-melnikov@mail.ru
Russian Federation, Novosibirsk