Specific Features of Depolarization of the Left and Right Atria in Rats with Alcoholic Cardiomyopathy
- Authors: Roshchevskaya I.M.1, Smirnova S.L.1, Tsorin I.B.2, Stolyaruk V.N.2, Nadorova A.V.2, Vititnova M.B.2, Kolik L.G.2, Kryzhanovskii S.A.2
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Affiliations:
- Department of Comparative Cardiology, Komi Research Center, Ural Division of the Russian Academy of Sciences
- V. V. Zakusov Research Institute of Pharmacology
- Issue: Vol 165, No 5 (2018)
- Pages: 617-620
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240602
- DOI: https://doi.org/10.1007/s10517-018-4226-3
- ID: 240602
Cite item
Abstract
Using a translation model of alcoholic cardiomyopathy in rats we showed the presence of an additional abnormal excitation focus in the area of the pulmonary vein lacunae in the left atrium and enhanced heterogeneity of the atrium depolarization pattern. These changes can determine electric instability of the myocardium and induce malignant heart rhythm disturbances including, sudden cardiac death.
About the authors
I. M. Roshchevskaya
Department of Comparative Cardiology, Komi Research Center, Ural Division of the Russian Academy of Sciences
Email: SAK-538@yandex.ru
Russian Federation, Syktyvkar, Komi Republic
S. L. Smirnova
Department of Comparative Cardiology, Komi Research Center, Ural Division of the Russian Academy of Sciences
Email: SAK-538@yandex.ru
Russian Federation, Syktyvkar, Komi Republic
I. B. Tsorin
V. V. Zakusov Research Institute of Pharmacology
Email: SAK-538@yandex.ru
Russian Federation, Moscow
V. N. Stolyaruk
V. V. Zakusov Research Institute of Pharmacology
Email: SAK-538@yandex.ru
Russian Federation, Moscow
A. V. Nadorova
V. V. Zakusov Research Institute of Pharmacology
Email: SAK-538@yandex.ru
Russian Federation, Moscow
M. B. Vititnova
V. V. Zakusov Research Institute of Pharmacology
Email: SAK-538@yandex.ru
Russian Federation, Moscow
L. G. Kolik
V. V. Zakusov Research Institute of Pharmacology
Email: SAK-538@yandex.ru
Russian Federation, Moscow
S. A. Kryzhanovskii
V. V. Zakusov Research Institute of Pharmacology
Author for correspondence.
Email: SAK-538@yandex.ru
Russian Federation, Moscow