In Vitro Study of Antitumor Effect of Antimicrobial Peptide Tachyplesin I in Combination with Cisplatin
- Authors: Kuzmin D.V.1, Emel’yanova A.A.1, Kalashnikova M.B.1, Panteleev P.V.1, Ovchinnikova T.V.1
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Affiliations:
- M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Issue: Vol 165, No 2 (2018)
- Pages: 220-224
- Section: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/240179
- DOI: https://doi.org/10.1007/s10517-018-4134-6
- ID: 240179
Cite item
Abstract
We studied combined effect of β-hairpin antimicrobial peptide tachyplesin I and cytotoxic agent cisplatin on tumor and normal human cell lines. MTT assay and flow cytometry showed that tachyplesin I selectively sensitized cancer cells to cisplatin in specified concentration ratios. In vitro experiments demonstrated that combined use of tachyplesin I and cisplatin allows decreasing the effective dose of the cytostatic thus reducing nonspecific toxicity.
About the authors
D. V. Kuzmin
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ovch@ibch.ru
Russian Federation, Moscow
A. A. Emel’yanova
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ovch@ibch.ru
Russian Federation, Moscow
M. B. Kalashnikova
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ovch@ibch.ru
Russian Federation, Moscow
P. V. Panteleev
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ovch@ibch.ru
Russian Federation, Moscow
T. V. Ovchinnikova
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Author for correspondence.
Email: ovch@ibch.ru
Russian Federation, Moscow