fMRI Responses in Healthy Individuals and in Patients with Mild Depression to Presentation of Pleasant and Unpleasant Images
- Authors: Mel’nikov M.E.1,2, Petrovskii E.D.3, Bezmaternykh D.D.1,2, Kozlova L.I.1,2, Shtark M.B.1,2, Savelov A.A.3, Shubina O.S.1, Natarova K.A.4
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Affiliations:
- Research Institute of Molecular Biology and Biophysics
- Novosibirsk State National Research University
- International Tomography Center, Siberian Division of Russian Academy of Sciences
- International Institute of Psychology and Psychotherapy
- Issue: Vol 164, No 5 (2018)
- Pages: 601-604
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239778
- DOI: https://doi.org/10.1007/s10517-018-4040-y
- ID: 239778
Cite item
Abstract
Patients with mild depression and apparently healthy individuals were presented images and asked to sort them into “pleasant” and “unpleasant” subsets. In both groups, the main differences between brain activation patterns during presentation of pleasant and unpleasant images were localized in the motor regions (precentral and postcentral gyrus) and in the cerebellum (p<0.05 with FWE correction). Most likely, these clusters are associated with motion (pressing a button in accordance with the instruction). According to the data of intergroup contrasts, patients with depression had less pronounced activation of frontal structures (middle frontal gyrus and other areas, including the white matter) in response to both positive and negative images (p<0.001). In healthy subjects, the response of the temporo-occipital areas (lingual and fusiform gyrus) to unpleasant stimuli was more intensive than in patients (p<0.001). This can be due to differences in the semantic image processing. Thus, in case of mild depression, the response of the amygdaloid complex, the key structure in the development in affective disorder, was not always observed. At the same time, the response of frontal and temporo-occipital regions has a certain potential as a biomarker of mild depression, although the reliability of the obtained data requires additional confirmation.
About the authors
M. E. Mel’nikov
Research Institute of Molecular Biology and Biophysics; Novosibirsk State National Research University
Author for correspondence.
Email: mikhail-melnikov@mail.ru
Russian Federation, Novosibirsk; Novosibirsk
E. D. Petrovskii
International Tomography Center, Siberian Division of Russian Academy of Sciences
Email: mikhail-melnikov@mail.ru
Russian Federation, Novosibirsk
D. D. Bezmaternykh
Research Institute of Molecular Biology and Biophysics; Novosibirsk State National Research University
Email: mikhail-melnikov@mail.ru
Russian Federation, Novosibirsk; Novosibirsk
L. I. Kozlova
Research Institute of Molecular Biology and Biophysics; Novosibirsk State National Research University
Email: mikhail-melnikov@mail.ru
Russian Federation, Novosibirsk; Novosibirsk
M. B. Shtark
Research Institute of Molecular Biology and Biophysics; Novosibirsk State National Research University
Email: mikhail-melnikov@mail.ru
Russian Federation, Novosibirsk; Novosibirsk
A. A. Savelov
International Tomography Center, Siberian Division of Russian Academy of Sciences
Email: mikhail-melnikov@mail.ru
Russian Federation, Novosibirsk
O. S. Shubina
Research Institute of Molecular Biology and Biophysics
Email: mikhail-melnikov@mail.ru
Russian Federation, Novosibirsk
K. A. Natarova
International Institute of Psychology and Psychotherapy
Email: mikhail-melnikov@mail.ru
Russian Federation, Novosibirsk