fMRI Responses in Healthy Individuals and in Patients with Mild Depression to Presentation of Pleasant and Unpleasant Images
- 作者: Mel’nikov M.1,2, Petrovskii E.3, Bezmaternykh D.1,2, Kozlova L.1,2, Shtark M.1,2, Savelov A.3, Shubina O.1, Natarova K.4
-
隶属关系:
- Research Institute of Molecular Biology and Biophysics
- Novosibirsk State National Research University
- International Tomography Center, Siberian Division of Russian Academy of Sciences
- International Institute of Psychology and Psychotherapy
- 期: 卷 164, 编号 5 (2018)
- 页面: 601-604
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239778
- DOI: https://doi.org/10.1007/s10517-018-4040-y
- ID: 239778
如何引用文章
详细
Patients with mild depression and apparently healthy individuals were presented images and asked to sort them into “pleasant” and “unpleasant” subsets. In both groups, the main differences between brain activation patterns during presentation of pleasant and unpleasant images were localized in the motor regions (precentral and postcentral gyrus) and in the cerebellum (p<0.05 with FWE correction). Most likely, these clusters are associated with motion (pressing a button in accordance with the instruction). According to the data of intergroup contrasts, patients with depression had less pronounced activation of frontal structures (middle frontal gyrus and other areas, including the white matter) in response to both positive and negative images (p<0.001). In healthy subjects, the response of the temporo-occipital areas (lingual and fusiform gyrus) to unpleasant stimuli was more intensive than in patients (p<0.001). This can be due to differences in the semantic image processing. Thus, in case of mild depression, the response of the amygdaloid complex, the key structure in the development in affective disorder, was not always observed. At the same time, the response of frontal and temporo-occipital regions has a certain potential as a biomarker of mild depression, although the reliability of the obtained data requires additional confirmation.
作者简介
M. Mel’nikov
Research Institute of Molecular Biology and Biophysics; Novosibirsk State National Research University
编辑信件的主要联系方式.
Email: mikhail-melnikov@mail.ru
俄罗斯联邦, Novosibirsk; Novosibirsk
E. Petrovskii
International Tomography Center, Siberian Division of Russian Academy of Sciences
Email: mikhail-melnikov@mail.ru
俄罗斯联邦, Novosibirsk
D. Bezmaternykh
Research Institute of Molecular Biology and Biophysics; Novosibirsk State National Research University
Email: mikhail-melnikov@mail.ru
俄罗斯联邦, Novosibirsk; Novosibirsk
L. Kozlova
Research Institute of Molecular Biology and Biophysics; Novosibirsk State National Research University
Email: mikhail-melnikov@mail.ru
俄罗斯联邦, Novosibirsk; Novosibirsk
M. Shtark
Research Institute of Molecular Biology and Biophysics; Novosibirsk State National Research University
Email: mikhail-melnikov@mail.ru
俄罗斯联邦, Novosibirsk; Novosibirsk
A. Savelov
International Tomography Center, Siberian Division of Russian Academy of Sciences
Email: mikhail-melnikov@mail.ru
俄罗斯联邦, Novosibirsk
O. Shubina
Research Institute of Molecular Biology and Biophysics
Email: mikhail-melnikov@mail.ru
俄罗斯联邦, Novosibirsk
K. Natarova
International Institute of Psychology and Psychotherapy
Email: mikhail-melnikov@mail.ru
俄罗斯联邦, Novosibirsk
![](/img/style/loading.gif)