Role of Copper Dyshomeostasis in the Pathogenesis of Parkinson’s Disease
- Authors: Karpenko M.N.1,2,3, Ilyicheva E.Y.1,2, Muruzheva Z.M.1, Milyukhina I.V.1, Orlov Y.A.2, Puchkova L.1,2,3
-
Affiliations:
- Institute of Experimental Medicine
- St. Petersburg National Research University of Information Technologies, Mechanics, and Optics (ITMO University)
- Peter the Great St. Petersburg Polytechnic University
- Issue: Vol 164, No 5 (2018)
- Pages: 596-600
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239774
- DOI: https://doi.org/10.1007/s10517-018-4039-4
- ID: 239774
Cite item
Abstract
Serum concentration of copper, immunoreactive polypeptides of ceruloplasmin and its oxidase activity, and the number of copper atoms per ceruloplasmin molecule were decreased in patients with Parkinson’s disease in comparison with the corresponding parameters in age-matched healthy individuals, but the ratio of apoceruloplasmin to holoceruloplasmin in patients with Parkinson’s disease was similar in both groups. Treatment of blood serum with Helex 100, a high-affinity copper chelator, revealed reduced content of labile copper atoms per ceruloplasmin molecule in patients with Parkinson’s disease in comparison with that in healthy controls. The mechanism underlying impaired metabolic incorporation of labile copper atoms into CP molecule is discussed as a possible cause of copper dyshomeostasis associated with Parkinson’s disease.
About the authors
M. N. Karpenko
Institute of Experimental Medicine; St. Petersburg National Research University of Information Technologies, Mechanics, and Optics (ITMO University); Peter the Great St. Petersburg Polytechnic University
Email: ilichevaey@gmail.com
Russian Federation, St. Petersburg; St. Petersburg; St. Petersburg
E. Yu. Ilyicheva
Institute of Experimental Medicine; St. Petersburg National Research University of Information Technologies, Mechanics, and Optics (ITMO University)
Author for correspondence.
Email: ilichevaey@gmail.com
Russian Federation, St. Petersburg; St. Petersburg
Z. M. Muruzheva
Institute of Experimental Medicine
Email: ilichevaey@gmail.com
Russian Federation, St. Petersburg
I. V. Milyukhina
Institute of Experimental Medicine
Email: ilichevaey@gmail.com
Russian Federation, St. Petersburg
Yu. A. Orlov
St. Petersburg National Research University of Information Technologies, Mechanics, and Optics (ITMO University)
Email: ilichevaey@gmail.com
Russian Federation, St. Petersburg
L.V. Puchkova
Institute of Experimental Medicine; St. Petersburg National Research University of Information Technologies, Mechanics, and Optics (ITMO University); Peter the Great St. Petersburg Polytechnic University
Email: ilichevaey@gmail.com
Russian Federation, St. Petersburg; St. Petersburg; St. Petersburg