Role of Copper Dyshomeostasis in the Pathogenesis of Parkinson’s Disease
- 作者: Karpenko M.1,2,3, Ilyicheva E.1,2, Muruzheva Z.1, Milyukhina I.1, Orlov Y.2, Puchkova L.1,2,3
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隶属关系:
- Institute of Experimental Medicine
- St. Petersburg National Research University of Information Technologies, Mechanics, and Optics (ITMO University)
- Peter the Great St. Petersburg Polytechnic University
- 期: 卷 164, 编号 5 (2018)
- 页面: 596-600
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239774
- DOI: https://doi.org/10.1007/s10517-018-4039-4
- ID: 239774
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详细
Serum concentration of copper, immunoreactive polypeptides of ceruloplasmin and its oxidase activity, and the number of copper atoms per ceruloplasmin molecule were decreased in patients with Parkinson’s disease in comparison with the corresponding parameters in age-matched healthy individuals, but the ratio of apoceruloplasmin to holoceruloplasmin in patients with Parkinson’s disease was similar in both groups. Treatment of blood serum with Helex 100, a high-affinity copper chelator, revealed reduced content of labile copper atoms per ceruloplasmin molecule in patients with Parkinson’s disease in comparison with that in healthy controls. The mechanism underlying impaired metabolic incorporation of labile copper atoms into CP molecule is discussed as a possible cause of copper dyshomeostasis associated with Parkinson’s disease.
作者简介
M. Karpenko
Institute of Experimental Medicine; St. Petersburg National Research University of Information Technologies, Mechanics, and Optics (ITMO University); Peter the Great St. Petersburg Polytechnic University
Email: ilichevaey@gmail.com
俄罗斯联邦, St. Petersburg; St. Petersburg; St. Petersburg
E. Ilyicheva
Institute of Experimental Medicine; St. Petersburg National Research University of Information Technologies, Mechanics, and Optics (ITMO University)
编辑信件的主要联系方式.
Email: ilichevaey@gmail.com
俄罗斯联邦, St. Petersburg; St. Petersburg
Z. Muruzheva
Institute of Experimental Medicine
Email: ilichevaey@gmail.com
俄罗斯联邦, St. Petersburg
I. Milyukhina
Institute of Experimental Medicine
Email: ilichevaey@gmail.com
俄罗斯联邦, St. Petersburg
Yu. Orlov
St. Petersburg National Research University of Information Technologies, Mechanics, and Optics (ITMO University)
Email: ilichevaey@gmail.com
俄罗斯联邦, St. Petersburg
L.V. Puchkova
Institute of Experimental Medicine; St. Petersburg National Research University of Information Technologies, Mechanics, and Optics (ITMO University); Peter the Great St. Petersburg Polytechnic University
Email: ilichevaey@gmail.com
俄罗斯联邦, St. Petersburg; St. Petersburg; St. Petersburg