Focal Unilateral Traumatic brain injury Causes Delayed Neurodegenerative Changes in the Brain of Rats
- Authors: Genrikhs E.E.1, Voronkov D.N.1, Kapkaeva M.R.1, Isaev N.K.1,2,3, Stelmashook E.V.1
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Affiliations:
- Research Center of Neurology, M. V. Lomonosov Moscow State University
- A. N. Belozersky Institute Of Physico-Chemical Biology, M. V. Lomonosov Moscow State University
- Faculty of Biology, M. V. Lomonosov Moscow State University
- Issue: Vol 164, No 2 (2017)
- Pages: 211-213
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239501
- DOI: https://doi.org/10.1007/s10517-017-3960-2
- ID: 239501
Cite item
Abstract
A cascade of pathological changes in the intact hemisphere developed in rats 6 months after focal unilateral traumatic brain injury: neuronal degeneration, hyperexpression of α-synuclein, APP (β-amyloid peptide precursor) protein, and glutamine synthetase in cells other than astrocytes. The development of these changes in the contralateral hemisphere indicated the emergence of extensive delayed neurodegenerative processes in the brain after traumatic brain injury, which were characteristic of diseases associated with pathological aging.
About the authors
E. E. Genrikhs
Research Center of Neurology, M. V. Lomonosov Moscow State University
Email: estelmash@mail.ru
Russian Federation, Moscow
D. N. Voronkov
Research Center of Neurology, M. V. Lomonosov Moscow State University
Email: estelmash@mail.ru
Russian Federation, Moscow
M. R. Kapkaeva
Research Center of Neurology, M. V. Lomonosov Moscow State University
Email: estelmash@mail.ru
Russian Federation, Moscow
N. K. Isaev
Research Center of Neurology, M. V. Lomonosov Moscow State University; A. N. Belozersky Institute Of Physico-Chemical Biology, M. V. Lomonosov Moscow State University; Faculty of Biology, M. V. Lomonosov Moscow State University
Email: estelmash@mail.ru
Russian Federation, Moscow; Moscow; Moscow
E. V. Stelmashook
Research Center of Neurology, M. V. Lomonosov Moscow State University
Author for correspondence.
Email: estelmash@mail.ru
Russian Federation, Moscow