Email this article Effects of Physiological Nitric Oxide Donor on Oxidative Metabolism in Rat Blood
- Authors: Martusevich A.K.1,2, Davydyuk A.V.2, Martusevich A.A.3, Kovaleva L.K.2
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Affiliations:
- Volga Region Federal Medical Research Center, Ministry of Health of the Russian Federation
- Kirov State Medical University, Ministry of Health of the Russian Federation
- N. I. Lobachevsky Nizhny Novgorod National Research State University
- Issue: Vol 163, No 5 (2017)
- Pages: 602-604
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239116
- DOI: https://doi.org/10.1007/s10517-017-3858-z
- ID: 239116
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Abstract
The effects of exogenous dinitrosyl iron complexes with glutathione ligands on the parameters of oxidative metabolism in the rat blood are studied. The intensity of LPO, total antioxidant activity, and MDA level in the plasma are compared in rats receiving intraperitoneal injections of saline without and with dinitrosyl iron complexes in various concentrations (0.15, 0.30, 0.45, and 0.60 mM). Glutathione—containing dinitrosyl iron complexes are characterized by antioxidant effect that non-linearly depended of the dose with optimum at 0.30-0.45 mM.
About the authors
A. K. Martusevich
Volga Region Federal Medical Research Center, Ministry of Health of the Russian Federation; Kirov State Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: cryst-mart@yandex.ru
Russian Federation, Nizhny Novgorod; Kirov
A. V. Davydyuk
Kirov State Medical University, Ministry of Health of the Russian Federation
Email: cryst-mart@yandex.ru
Russian Federation, Kirov
A. A. Martusevich
N. I. Lobachevsky Nizhny Novgorod National Research State University
Email: cryst-mart@yandex.ru
Russian Federation, Nizhny Novgorod
L. K. Kovaleva
Kirov State Medical University, Ministry of Health of the Russian Federation
Email: cryst-mart@yandex.ru
Russian Federation, Kirov
