Involvement of Semaphorin (Sema4D) in T-Dependent Activation of B Cells
- Authors: Kuklina Е.М.1, Nekrasova I.V.1, Valieva Y.V.1
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Affiliations:
- Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences
- Issue: Vol 163, No 4 (2017)
- Pages: 447-450
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238979
- DOI: https://doi.org/10.1007/s10517-017-3825-8
- ID: 238979
Cite item
Abstract
The involvement of endogenous semaphorin (Sema4D) into the key stage of T-dependent differentiation of B cells, formation of plasmoblasts, was demonstrated in vitro in T/B cell co-culture under conditions of polyclonal activation of T cells. The effect of semaphorin was not associated with activation of high-affinity Sema4D receptor plexin B1, but involves lowaffinity receptor CD72. These data indicate that Sema4D-dependent signal regulates not only the initial stage of B-cell activation, proliferative response to the antigen, but also further differentiation of B cells into plasma cells.
About the authors
Е. М. Kuklina
Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences
Author for correspondence.
Email: ibis_07@mail.ru
Russian Federation, Perm
I. V. Nekrasova
Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences
Email: ibis_07@mail.ru
Russian Federation, Perm
Yu. V. Valieva
Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences
Email: ibis_07@mail.ru
Russian Federation, Perm