Involvement of Semaphorin (Sema4D) in T-Dependent Activation of B Cells
- Autores: Kuklina Е.1, Nekrasova I.1, Valieva Y.1
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Afiliações:
- Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences
- Edição: Volume 163, Nº 4 (2017)
- Páginas: 447-450
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238979
- DOI: https://doi.org/10.1007/s10517-017-3825-8
- ID: 238979
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Resumo
The involvement of endogenous semaphorin (Sema4D) into the key stage of T-dependent differentiation of B cells, formation of plasmoblasts, was demonstrated in vitro in T/B cell co-culture under conditions of polyclonal activation of T cells. The effect of semaphorin was not associated with activation of high-affinity Sema4D receptor plexin B1, but involves lowaffinity receptor CD72. These data indicate that Sema4D-dependent signal regulates not only the initial stage of B-cell activation, proliferative response to the antigen, but also further differentiation of B cells into plasma cells.
Sobre autores
Е. Kuklina
Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences
Autor responsável pela correspondência
Email: ibis_07@mail.ru
Rússia, Perm
I. Nekrasova
Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences
Email: ibis_07@mail.ru
Rússia, Perm
Yu. Valieva
Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences
Email: ibis_07@mail.ru
Rússia, Perm