Study of Proliferative Activity of Vaginal Epithelium in Women with Stress Urinary Incontinence Treated by Er:YAG Laser
- Authors: Lapii G.A.1, Yakovleva A.Y.1, Neimark A.I.2, Lushnikova E.L.1
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Affiliations:
- Institute of Molecular Pathology and Pathomorphology
- Altai State Medical University
- Issue: Vol 163, No 2 (2017)
- Pages: 280-283
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238818
- DOI: https://doi.org/10.1007/s10517-017-3784-0
- ID: 238818
Cite item
Abstract
The expression of Ki-67 proliferation marker was studied in vaginal biopsy specimens from women with stress urinary incontinence treated using a Fotona nonablative erbium laser. Cells expressing Ki-67 were located in all cases in the parabasal and basal levels of stratified squamous epithelium, the index of labeled nuclei before Er:YAG laser exposure was 19.05±2.86%. After 1-2 months of laser therapy, the index of labeled nuclei in the epithelium increased significantly and reached 31.79±2.25%. These changes were interpreted as a result of epithelial-stromal interactions. Presumably, the increase in proliferative activity of the vaginal epithelium after exposure to Er:YAG laser was due to the presence of an appreciable level of synthetically active fibroblasts in the subepithelial stroma.
About the authors
G. A. Lapii
Institute of Molecular Pathology and Pathomorphology
Author for correspondence.
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
A. Yu. Yakovleva
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
A. I. Neimark
Altai State Medical University
Email: pathol@inbox.ru
Russian Federation, Barnaul
E. L. Lushnikova
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Russian Federation, Novosibirsk