The Role of Free Radical Oxidation in the Development of Experimental Urate Nephropathy
- Authors: Perfil’ev V.Y.1, Zverev Y.F.1, Zharikov A.Y.1, Bryukhanov V.M.1
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Affiliations:
- Department of pharmacology, Altai State Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 163, No 1 (2017)
- Pages: 28-30
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238623
- DOI: https://doi.org/10.1007/s10517-017-3730-1
- ID: 238623
Cite item
Abstract
We studied the dynamics of activity of antioxidant enzymes under conditions of experimental urate kidney damage in rats. Combined administration of uric (0.145 g) and oxonium (0.3 g) acids to laboratory animals modulated free radical oxidation in the kidneys, and especially, in the blood. During the week 1, activity of free radical processes decreased, which was probably determined by the antioxidant effect of increasing blood concentration of uric acid. After 2-3 weeks of experimental pathology, the development of oxidative stress was observed, probably due to predominance of prooxidant activity of uric acid.
About the authors
V. Yu. Perfil’ev
Department of pharmacology, Altai State Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: 1991ps@mail.ru
Russian Federation, Barnaul
Ya. F. Zverev
Department of pharmacology, Altai State Medical University, Ministry of Health of the Russian Federation
Email: 1991ps@mail.ru
Russian Federation, Barnaul
A. Yu. Zharikov
Department of pharmacology, Altai State Medical University, Ministry of Health of the Russian Federation
Email: 1991ps@mail.ru
Russian Federation, Barnaul
V. M. Bryukhanov
Department of pharmacology, Altai State Medical University, Ministry of Health of the Russian Federation
Email: 1991ps@mail.ru
Russian Federation, Barnaul