The Role of Free Radical Oxidation in the Development of Experimental Urate Nephropathy
- 作者: Perfil’ev V.1, Zverev Y.1, Zharikov A.1, Bryukhanov V.1
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隶属关系:
- Department of pharmacology, Altai State Medical University, Ministry of Health of the Russian Federation
- 期: 卷 163, 编号 1 (2017)
- 页面: 28-30
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238623
- DOI: https://doi.org/10.1007/s10517-017-3730-1
- ID: 238623
如何引用文章
详细
We studied the dynamics of activity of antioxidant enzymes under conditions of experimental urate kidney damage in rats. Combined administration of uric (0.145 g) and oxonium (0.3 g) acids to laboratory animals modulated free radical oxidation in the kidneys, and especially, in the blood. During the week 1, activity of free radical processes decreased, which was probably determined by the antioxidant effect of increasing blood concentration of uric acid. After 2-3 weeks of experimental pathology, the development of oxidative stress was observed, probably due to predominance of prooxidant activity of uric acid.
作者简介
V. Perfil’ev
Department of pharmacology, Altai State Medical University, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: 1991ps@mail.ru
俄罗斯联邦, Barnaul
Ya. Zverev
Department of pharmacology, Altai State Medical University, Ministry of Health of the Russian Federation
Email: 1991ps@mail.ru
俄罗斯联邦, Barnaul
A. Zharikov
Department of pharmacology, Altai State Medical University, Ministry of Health of the Russian Federation
Email: 1991ps@mail.ru
俄罗斯联邦, Barnaul
V. Bryukhanov
Department of pharmacology, Altai State Medical University, Ministry of Health of the Russian Federation
Email: 1991ps@mail.ru
俄罗斯联邦, Barnaul
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