Adrenoceptors in Dopaminergic Regulation of Rat Myocardial Contractility in Rats During Ontogeny

G. A. Bilalova; F. G. Sitdikov; N. B. Dikopol’skaya; M. V. Shaikhelislamova; T. L. Zefirov

doi:10.1007/s10517-017-3709-y

Adrenoceptors in Dopaminergic Regulation of Rat Myocardial Contractility in Rats During Ontogeny

Authors: Bilalova G.A.¹, Sitdikov F.G.¹, Dikopol’skaya N.B.¹, Shaikhelislamova M.V.¹, Zefirov T.L.¹
Affiliations:
1. Department of Human Health Protection, Kazan (Volga Region) Federal University
Issue: Vol 162, No 6 (2017)
Pages: 769-772
Section: Article
URL: https://journals.rcsi.science/0007-4888/article/view/238547
DOI: https://doi.org/10.1007/s10517-017-3709-y
ID: 238547

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Abstract

The effects of different dopamine concentrations on contractility of myocardium with blocked α- or β-adrenoceptors were examined in vitro in 21- and 100-day old rats. In myocardial strips with blocked α-adrenoceptors, dopamine (10^—5 M) increased the right atrial contractile force. By contrast, this neurotransmitter (10^—9-10^—5 M) reduced the contractile force of atrial and ventricular strips with blocked β-adrenoceptors.