Experimental Study of a Radiopharmaceutical Agent Based on Modified Fatty Acid Labeled with Technetium-99m
- Authors: Sazonova S.I.1, Il’yushenkova Y.N.1, Lishmanov Y.B.1, Tsibul’nikov S.V.1, Skuridin V.S.2, Nesterov E.A.2, Varlamova N.V.2, Il’ina E.A.2, Filimonov V.D.2, Belyanin M.V.2, Stepanova E.V.2, Minin S.M.2
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Affiliations:
- Research Institute of Cardiology
- National Research Tomsk Polytechnic University
- Issue: Vol 162, No 6 (2017)
- Pages: 746-749
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238518
- DOI: https://doi.org/10.1007/s10517-017-3703-4
- ID: 238518
Cite item
Abstract
Using rat model of coronary occlusion, we studied pharmacokinetics and the efficiency of a new radiopharmaceutical agent 99mTc-PDA-DTPA intended for diagnostics of changes in myocardial metabolism and its analogue 123I-PMPDA. 99mTc-PDA-DTPA was eliminated mostly by the kidneys and maximal concentration in the heart was attained within 60 min after intravenous injection; no accumulation in the area of myocardial infarction was observed. The studied substance was inferior to its analogue 123I-PMPDA by the quality of scintigraphic visualization of the heart.
About the authors
S. I. Sazonova
Research Institute of Cardiology
Author for correspondence.
Email: sazonova_si@mail.ru
Russian Federation, Tomsk
Yu. N. Il’yushenkova
Research Institute of Cardiology
Email: sazonova_si@mail.ru
Russian Federation, Tomsk
Yu. B. Lishmanov
Research Institute of Cardiology
Email: sazonova_si@mail.ru
Russian Federation, Tomsk
S. V. Tsibul’nikov
Research Institute of Cardiology
Email: sazonova_si@mail.ru
Russian Federation, Tomsk
V. S. Skuridin
National Research Tomsk Polytechnic University
Email: sazonova_si@mail.ru
Russian Federation, Tomsk
E. A. Nesterov
National Research Tomsk Polytechnic University
Email: sazonova_si@mail.ru
Russian Federation, Tomsk
N. V. Varlamova
National Research Tomsk Polytechnic University
Email: sazonova_si@mail.ru
Russian Federation, Tomsk
E. A. Il’ina
National Research Tomsk Polytechnic University
Email: sazonova_si@mail.ru
Russian Federation, Tomsk
V. D. Filimonov
National Research Tomsk Polytechnic University
Email: sazonova_si@mail.ru
Russian Federation, Tomsk
M. V. Belyanin
National Research Tomsk Polytechnic University
Email: sazonova_si@mail.ru
Russian Federation, Tomsk
E. V. Stepanova
National Research Tomsk Polytechnic University
Email: sazonova_si@mail.ru
Russian Federation, Tomsk
S. M. Minin
National Research Tomsk Polytechnic University
Email: sazonova_si@mail.ru
Russian Federation, Tomsk