Experimental Study of a Radiopharmaceutical Agent Based on Modified Fatty Acid Labeled with Technetium-99m

S. I. Sazonova; Yu. N. Il’yushenkova; Yu. B. Lishmanov; S. V. Tsibul’nikov; V. S. Skuridin; E. A. Nesterov; N. V. Varlamova; E. A. Il’ina; V. D. Filimonov; M. V. Belyanin; E. V. Stepanova; S. M. Minin

doi:10.1007/s10517-017-3703-4

Experimental Study of a Radiopharmaceutical Agent Based on Modified Fatty Acid Labeled with Technetium-99m

Authors: Sazonova S.I.¹, Il’yushenkova Y.N.¹, Lishmanov Y.B.¹, Tsibul’nikov S.V.¹, Skuridin V.S.², Nesterov E.A.², Varlamova N.V.², Il’ina E.A.², Filimonov V.D.², Belyanin M.V.², Stepanova E.V.², Minin S.M.²
Affiliations:
1. Research Institute of Cardiology
2. National Research Tomsk Polytechnic University
Issue: Vol 162, No 6 (2017)
Pages: 746-749
Section: Article
URL: https://journals.rcsi.science/0007-4888/article/view/238518
DOI: https://doi.org/10.1007/s10517-017-3703-4
ID: 238518

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Abstract

Using rat model of coronary occlusion, we studied pharmacokinetics and the efficiency of a new radiopharmaceutical agent ^99mTc-PDA-DTPA intended for diagnostics of changes in myocardial metabolism and its analogue ¹²³I-PMPDA. ^99mTc-PDA-DTPA was eliminated mostly by the kidneys and maximal concentration in the heart was attained within 60 min after intravenous injection; no accumulation in the area of myocardial infarction was observed. The studied substance was inferior to its analogue 123I-PMPDA by the quality of scintigraphic visualization of the heart.

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Experimental Study of a Radiopharmaceutical Agent Based on Modified Fatty Acid Labeled with Technetium-99m

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Abstract

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