Changes in the Structure of the Thymus under Conditions of Various Treatments for Experimental Mammary Tumor
- Authors: Kazakov O.V.1, Kabakov A.V.1, Poveshchenko A.F.1,2, Ishchenko I.Y.1, Poveshchenko O.V.1,3, Strunkin D.N.1, Raiter T.V.1, Michurina S.V.1, Konenkov V.I.1
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Affiliations:
- Research Institute of Clinical and Experimental Lymphology
- Novosibirsk State Medical University, Ministry of Health of the Russian Federation
- Novosibirsk State Pedagogical University
- Issue: Vol 162, No 5 (2017)
- Pages: 654-657
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238433
- DOI: https://doi.org/10.1007/s10517-017-3680-7
- ID: 238433
Cite item
Abstract
Morphological changes in the thymus of female Wistar rats with experimental mammary gland carcinomas were studied. After adjuvant therapy, the area of the cortical matter and density of parenchymal cells in the thymus decreased, while areas of the medulla, connective tissue, and content of immunoblasts and macrophages increased. In the thymuses of rats receiving exogenous DNA, morphological signs of activation of the lymphoid and epithelial components were found: areas of the cortex and medulla, glandular and connective tissue corresponded to the values in intact animals, the counts of lymphocytes in the central part of the cortical matter and of macrophages in all zones of the thymus increased, and lymphocyte migration from the thymus increased (in comparison with the chemotherapy group).
About the authors
O. V. Kazakov
Research Institute of Clinical and Experimental Lymphology
Author for correspondence.
Email: kazakoff_oleg@mail.ru
Russian Federation, Novosibirsk
A. V. Kabakov
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
Russian Federation, Novosibirsk
A. F. Poveshchenko
Research Institute of Clinical and Experimental Lymphology; Novosibirsk State Medical University, Ministry of Health of the Russian Federation
Email: kazakoff_oleg@mail.ru
Russian Federation, Novosibirsk; Novosibirsk
I. Yu. Ishchenko
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
Russian Federation, Novosibirsk
O. V. Poveshchenko
Research Institute of Clinical and Experimental Lymphology; Novosibirsk State Pedagogical University
Email: kazakoff_oleg@mail.ru
Russian Federation, Novosibirsk; Novosibirsk
D. N. Strunkin
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
Russian Federation, Novosibirsk
T. V. Raiter
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
Russian Federation, Novosibirsk
S. V. Michurina
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
Russian Federation, Novosibirsk
V. I. Konenkov
Research Institute of Clinical and Experimental Lymphology
Email: kazakoff_oleg@mail.ru
Russian Federation, Novosibirsk