Cystatin C as a Marker of Progressing Cardiovascular Events during Coronary Heart Disease
- Authors: Gevorgyan M.M.1, Voronina N.P.2, Goncharova N.V.1, Kozaruk T.V.2, Russkikh G.S.1, Bogdanova L.A.3, Korolenko T.A.1
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Affiliations:
- Research Institute of Physiology and Fundamental Medicine
- Research Institute of Biochemistry
- Research Institute of Molecular Pathology and Pathomorphology
- Issue: Vol 162, No 4 (2017)
- Pages: 421-424
- Section: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/238274
- DOI: https://doi.org/10.1007/s10517-017-3630-4
- ID: 238274
Cite item
Abstract
The role of cystatin C, an inhibitor of cysteine proteases, as an alternative and potent predictor of acute cardiovascular events in coronary heart disease (CHD) patients was examined and compared to that of other markers of cardiorenal abnormalities. The patients with CHD demonstrated elevated serum cystatin C, especially in cases with serious risk of cardiovascular complications. In comparison with other indicators of cardiorenal dysfunction, cystatin C can be viewed as an alternative predictor of cardiovascular complications, although its sensitivity is inferior to that of high-sensitivity C-reactive protein and natriuretic peptide.
About the authors
M. M. Gevorgyan
Research Institute of Physiology and Fundamental Medicine
Email: t.a.korolenko@physiol.ru
Russian Federation, Novosibirsk
N. P. Voronina
Research Institute of Biochemistry
Email: t.a.korolenko@physiol.ru
Russian Federation, Novosibirsk
N. V. Goncharova
Research Institute of Physiology and Fundamental Medicine
Email: t.a.korolenko@physiol.ru
Russian Federation, Novosibirsk
T. V. Kozaruk
Research Institute of Biochemistry
Email: t.a.korolenko@physiol.ru
Russian Federation, Novosibirsk
G. S. Russkikh
Research Institute of Physiology and Fundamental Medicine
Email: t.a.korolenko@physiol.ru
Russian Federation, Novosibirsk
L. A. Bogdanova
Research Institute of Molecular Pathology and Pathomorphology
Email: t.a.korolenko@physiol.ru
Russian Federation, Novosibirsk
T. A. Korolenko
Research Institute of Physiology and Fundamental Medicine
Author for correspondence.
Email: t.a.korolenko@physiol.ru
Russian Federation, Novosibirsk
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