New Experimental Model of Rat Risk Behavior. Effects of Nicotine and Phenazepam
- Authors: Sudakov S.K.1, Nazarova G.A.1, Alekseeva E.V.1
-
Affiliations:
- P. K. Anokhin Research Institute of Normal Physiology
- Issue: Vol 162, No 3 (2017)
- Pages: 409-411
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238262
- DOI: https://doi.org/10.1007/s10517-017-3627-z
- ID: 238262
Cite item
Abstract
We described a new model of risk behavior in rats that allows selection of animals predisposed to risk behavior in the absence of other biological motivations. Phenazepam administration did not change the intensity of risk behavior in “risky” animals, but stimulated risk behavior in rats that were not predisposed to it. Nicotine inhibited risk behavior in “risky” animals and strengthened it in “cautious” rats. In the intermediate group, the drugs did not induce significant changes. A similar effect of the drugs was observed in the previous models. More complex effect of nicotine on the risk behavior may be explained by the absence of severe food motivation typical for the early models.
About the authors
S. K. Sudakov
P. K. Anokhin Research Institute of Normal Physiology
Author for correspondence.
Email: s-sudakov@nphys.ru
Russian Federation, Moscow
G. A. Nazarova
P. K. Anokhin Research Institute of Normal Physiology
Email: s-sudakov@nphys.ru
Russian Federation, Moscow
E. V. Alekseeva
P. K. Anokhin Research Institute of Normal Physiology
Email: s-sudakov@nphys.ru
Russian Federation, Moscow