Involvement of the Coronary Bed in Patients with Coronary Heart Disease against the Background of Primarily Coronary and Generalized Atherosclerosis
- Authors: Bakarev M.A.1, Karpova A.A.1, Pichigin V.I.1, Nikityuk D.B.1, Lushnikova E.L.1
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Affiliations:
- Institute of Molecular Pathology and Pathomorphology
- Issue: Vol 162, No 2 (2016)
- Pages: 283-287
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238125
- DOI: https://doi.org/10.1007/s10517-016-3595-8
- ID: 238125
Cite item
Abstract
Significant associations between clinical history factors, lipid metabolism parameters, and type of atherosclerotic process (area of vascular lesions and severity of clinical manifestations) were detected. The predominance of generalized atherosclerosis in chronic coronary heart disease group was associated with patients’ age, more incident excessive body weight and type 2 diabetes mellitus, and more severe course of arterial hypertension. Increased lipid spectrum atherogenicity was significantly more often observed in generalized atherosclerosis in the myocardial infarction group. Angiography and postmortem examination of coronary arteries detected two trends of atherogenic remodeling of the coronary vessels: more pronounced stenosis of the main vessels in autopsy specimens from myocardial infarction patients with mainly coronary atherosclerosis and more extensive coronary bed involvement in chronic coronary heart disease patients with generalized atherosclerosis.
About the authors
M. A. Bakarev
Institute of Molecular Pathology and Pathomorphology
Author for correspondence.
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
A. A. Karpova
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
V. I. Pichigin
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
D. B. Nikityuk
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
E. L. Lushnikova
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Russian Federation, Novosibirsk